Beyond Supplements with Alan Graves on Funding Clinical Trials and Longevity Research

Daphna sat down with Alan Graves, founder of DoNotAge, for an in-depth conversation about what it takes to make longevity science more credible, more collaborative and more accessible.After a serious health decline in his late twenties, Alan entered the longevity field after learning that ageing may be more malleable than he had once thought. He went on to build DoNotAge as a self-funded health research organisation, using consumer supplements to help fund ageing research, support external labs and emerging researchers, provide high-purity ingredients for independent studies, and translate complex science into language people can actually understand.The conversation covers why longevity science is still difficult to access, why the supplement industry has a credibility problem, and how marketing, underdosing and weak “science-backed” claims have made it hard for consumers to know what to trust.Alan also discusses the realities of clinical trials, why they are slow and expensive, and the studies DoNotAge is currently supporting or planning, including work around spermidine, NAD, Crohn’s disease, berberine and biological age clocks.In striving to make longevity easier and more practical, Alan has also introduced a one-a-day sachet designed to simplify adherence. They also explore his focus on sirtuin 6 activation, DoNotAge’s free London conference, and the wider aim of making longevity more affordable, practical and collaborative.DoNotAge.org is a health research organisation.You can learn more at https://routine.donotage.org00:00 Welcome and Guest Intro02:52 Alan’s Unlikely Origin Story04:34 From Self-Experiment to Do Not Age06:45 Funding Gap and New Model08:12 Democratising Longevity Science09:48 Research Company Not Supplements11:09 Why Clinical Trials Take Years12:50 How Do Not Age Is Structured15:09 Supporting Labs Worldwide18:01 Supplement Industry Credibility Crisis21:01 How Consumers Verify Claims22:42 Stepping Down as CEO25:11 Choosing Which Research to Fund26:45 Upcoming Trials and What’s Next28:10 Basics Before Supplements31:43 Testing and Biological Age33:24 The One-a-Day Sachet Idea36:03 Clinical Trials Pipeline36:55 Making Longevity Affordable39:58 Pricing Ethics and Dosage41:33 Hype vs Evidence in Longevity44:51 Who Needs Supplements When46:55 Free Unbiased Science Conference53:02 What Excites Him Next54:08 SIRT6 Activator Deep Dive58:30 Why Healthcare Won’t Adopt It01:01:44 Boxing, Balance, and Ageing Goals01:04:41 Rapid Fire and Wrap Up01:07:15 Host Takeaways and Conclusion