EPISODE · May 28, 2026 · 59 MIN
Brain Fog, Low Libido, Night Wakes with Hormone & GLP-1 Expert Jackie Giannelli
from Lust in Translation · host Natassia Miller
Why are women's health issues often brushed off as “just part of aging”?In this eye-opening episode, Natassia sits down with board-certified family nurse practitioner, women's longevity and sexual medicine expert Jackie Giannelli to unpack the truth about perimenopause, menopause, libido, hormone replacement therapy, GLP-1 medications, hair loss, testosterone, vaginal estrogen, peptides, and sexual wellness. They explore why so many women feel dismissed when experiencing brain fog, fatigue, low desire, anxiety, and disrupted sleep and what can actually be done about it. From the controversy surrounding hormone therapy and breast cancer fears to the surprising effects of GLP-1 medications on libido and pleasure, this conversation challenges outdated medical narratives and offers practical insights for women who want to reclaim their vitality, confidence, relationships, and long-term health. If you've ever wondered whether feeling “flat” is normal, this episode may change the way you think about aging and wellness.00:00 – Welcome and introduction01:15 – Why women feel dismissed by healthcare02:58 – The first signs of perimenopause05:25 – Sleep, libido, brain fog, and hormone decline06:25 – Normal vs. optimal hormone levels09:41 – Medical gaslighting and menopause care11:32 – When hormones aren't the whole story13:05 – Testosterone therapy for women15:03 – Understanding estrogen, progesterone, and hormone balance17:28 – Bioidentical vs. synthetic hormones19:19 – The Women's Health Initiative controversy22:04 – Breast cancer fears and hormone therapy24:52 – Feeling flat, dopamine, and SSRIs26:10 – GLP-1 medications and sexual side effects29:20 – Combining hormones with GLP-1 treatment32:08 – Long-term concerns about GLP-1 medications36:12 – Hair loss, hormones, and weight loss drugs41:37 – Peptides explained44:01 – The peptide regulation gray area46:00 – PT-141, Addyi, and female libido treatments51:16 – Why vaginal estrogen is underused54:13 – Designing a home for intimacy and connection57:08 – The science of music and arousal59:00 – Closing thoughtsFollow Jackie Giannelli on InstagramOn this note: It’s really hard to feel sexy when your vagina feels off. If you’re bracing for irritation, infections, or yet another post‑sex UTI, it’s almost impossible to stay present in the bedroom. Momotaro Apotheca offers organic solutions that Natassia uses everyday to take care of her intimate health—from their soothing balm, Salve, to their UTI supplement, probiotic, and yeast infection suppository. Build your own ritual at https://momotaroapotheca.com/discount/lust and get 20% off with code LUST.⸻Lust in Translation PodcastSubscribe to our newsletter for exclusive insights: lustintranslation.com Follow us on Instagram: https://www.instagram.com/lustintranslationpod/ Follow Natassia on on Instagram: https://www.instagram.com/natassiamiller/
What this episode covers
Why are women's health issues often brushed off as “just part of aging”?In this eye-opening episode, Natassia sits down with board-certified family nurse practitioner, women's longevity and sexual medicine expert Jackie Giannelli to unpack the truth about perimenopause, menopause, libido, hormone replacement therapy, GLP-1 medications, hair loss, testosterone, vaginal estrogen, peptides, and sexual wellness. They explore why so many women feel dismissed when experiencing brain fog, fatigue, low desire, anxiety, and disrupted sleep and what can actually be done about it. From the controversy surrounding hormone therapy and breast cancer fears to the surprising effects of GLP-1 medications on libido and pleasure, this conversation challenges outdated medical narratives and offers practical insights for women who want to reclaim their vitality, confidence, relationships, and long-term health. If you've ever wondered whether feeling “flat” is normal, this episode may change the way you think about aging and wellness.00:00 – Welcome and introduction01:15 – Why women feel dismissed by healthcare02:58 – The first signs of perimenopause05:25 – Sleep, libido, brain fog, and hormone decline06:25 – Normal vs. optimal hormone levels09:41 – Medical gaslighting and menopause care11:32 – When hormones aren't the whole story13:05 – Testosterone therapy for women15:03 – Understanding estrogen, progesterone, and hormone balance17:28 – Bioidentical vs. synthetic hormones19:19 – The Women's Health Initiative controversy22:04 – Breast cancer fears and hormone therapy24:52 – Feeling flat, dopamine, and SSRIs26:10 – GLP-1 medications and sexual side effects29:20 – Combining hormones with GLP-1 treatment32:08 – Long-term concerns about GLP-1 medications36:12 – Hair loss, hormones, and weight loss drugs41:37 – Peptides explained44:01 – The peptide regulation gray area46:00 – PT-141, Addyi, and female libido treatments51:16 – Why vaginal estrogen is underused54:13 – Designing a home for intimacy and connection57:08 – The science of music and arousal59:00 – Closing thoughtsFollow Jackie Giannelli on InstagramOn this note: It’s really hard to feel sexy when your vagina feels off. If you’re bracing for irritation, infections, or yet another post‑sex UTI, it’s almost impossible to stay present in the bedroom. Momotaro Apotheca offers organic solutions that Natassia uses everyday to take care of her intimate health—from their soothing balm, Salve, to their UTI supplement, probiotic, and yeast infection suppository. Build your own ritual at https://momotaroapotheca.com/discount/lust and get 20% off with code LUST.⸻Lust in Translation PodcastSubscribe to our newsletter for exclusive insights: lustintranslation.com Follow us on Instagram: https://www.instagram.com/lustintranslationpod/ Follow Natassia on on Instagram: https://www.instagram.com/natassiamiller/
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Brain Fog, Low Libido, Night Wakes with Hormone & GLP-1 Expert Jackie Giannelli
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