BRAIN-MAGNET Atlas

This release contains only the music track from Base by Base Episode 213. Song title: BRAIN-MAGNET AtlasOriginal Base by Base episode: 213: BRAIN-MAGNET: a functional atlas for non-coding variantsOriginal episode link: https://basebybase.castos.com/episodes/brain-magnet-ncre-atlas Article metadata:Article title: BRAIN-MAGNET: A functional genomics atlas for interpretation of non-coding variantsJournal: CellDOI: 10.1016/j.cell.2025.10.029Reference: Deng R., Perenthaler E., Nikoncuk A., et al., BRAIN-MAGNET: A functional genomics atlas for interpretation of non-coding variants, Cell 189, 1–20 (2026). https://doi.org/10.1016/j.cell.2025.10.029 Lyrics:[Verse]BRAIN-MAGNET, a convolutional neural network trained on 148,198 functionally tested non-coding regulatory elementsA functional genomics atlas for interpretation of non-coding variantsA functional genomics atlas of 148,198 regulatory regions in neural stem cellsComparative-ChIP-STARR-seq identifies primed non-coding regulatory elements [Chorus]Predicts enhancer activity directly from DNA sequence and identifies nucleotides essential for functionPrioritize disease-relevant non-coding variants, advancing functional interpretation of the regulatory genomeIn neurodevelopment and neurological diseaseFine-mapping of GWAS loci and prioritizing candidate disease-causing rare non-coding variants [Bridge]BRAIN-MAGNET predicts NCRE activity from DNA sequence and identifies nucleotides required for NCRE functionProvides gene regulatory insights into neural stem cells and evidence of NCRE priming already in embryonic stem cells for later neural activityTogether, this NCRE atlas and BRAIN-MAGNET represent a powerful resource, possibly aiding the identification of previously unrecognized enhanceropathies