Breaking Free From Depression

Depression is often mistaken for ordinary sadness, but clinically it is something profoundly different: a medical illness that can alter the way the brain processes emotion, motivation, and even hope itself.In this episode of Road to Resilience, host Stephen Calabria speaks with James Murrough, MD, PhD, to discuss how groundbreaking neuroimaging research explains why depression may leave the brain "entrapped" in inefficient patterns of activity, The conversation explores the difference between sadness and clinical depression, why chronic stress can reshape the brain, how behavioral therapy and medication help people break free from depression's grip, and why the brain's extraordinary capacity for change offers genuine reason for hope.Visit https://www.mountsinai.org/clinical-trials to see if you're eligible to enroll in a clinical trial with the Mount Sinai Health System. Check out more episodes of Road to Resilience —as well as guest pictures, transcripts, and more— on the Mount Sinai website.If this episode inspired you, please consider supporting the Mount Sinai Health System. As a registered 501(c)(3) nonprofit, we rely on philanthropy to advance compassionate patient care, groundbreaking research, and medical education. Your generosity helps make conversations like this possible—and fuels the work behind them. To learn more or make a gift, visit give.mountsinai.org.Visit https://www.mountsinai.org/clinical-trials to see if you're eligible to enroll in a clinical trial with the Mount Sinai Health System. Check out more episodes of Road to Resilience—as well as guest pictures, transcripts, and more—on the Mount Sinai website.