Breaking "Wine O'Clock": Psilocybin, Saffron, Microdosing and Upgrading Women's Mental Health with Keegan Downer episode artwork

EPISODE · Feb 19, 2026 · 59 MIN

Breaking "Wine O'Clock": Psilocybin, Saffron, Microdosing and Upgrading Women's Mental Health with Keegan Downer

from Biohacking with Brittany

Keegan Downer (Founder of mindfulMEDS) shares how he went from alcohol addiction and a near-suicidal breaking point, to recovery and to building one of Canada's most recognized microdosing education brands, and why psilocybin doesn't have to be "woo."  We also get super practical: What microdosing actually feels like day-to-day, why it can hit women differently (especially moms), how psilocybin compares to SSRIs (Selective Serotonin Reuptake Inhibitor) when it comes to emotional processing, and why "wine o'clock" culture is quietly keeping so many women stuck in a stress-and-numb cycle. Want protocols built specifically for women, live coaching, and real talk about peptides and longevity? That's what The LongHer Life is for. Private. Uncensored. Ongoing. https://biohackingbrittany.com/pages/longherlife WE TALK ABOUT:  05:40 - Keegan's life collapse that led to addiction and the "rooftop moment"  07:45 - Rebuilding purpose after rehab and the anxiety attack that changed everything  09:10 - Why microdosing went from "nobody's talking about this" to mainstream fast  12:35 - The day-13 breakthrough and the microdosing study that launched his mission  19:30 - Why psilocybin and SSRIs create totally different emotional outcomes  23:20 - When microdosing feels "too strong" and how dose + setting change everything  28:40 - The dose reality check: "microdose" vs "creative dose" and why sensitivity matters  38:20 - Why women (especially moms) are the fastest-growing microdosing segment  41:05 - "Wine o'clock" culture, addiction masking, and the uncomfortable truth  44:00 - Brainbow: The saffron extract approach for mood, sleep, and nervous system support  57:10 - Where to learn more, the free microdosing guide, and weekly consults RESOURCES: Want protocols built specifically for women, live coaching, and real talk about peptides and longevity? That's what The LongHer Life is for. Private. Uncensored. Ongoing. https://biohackingbrittany.com/pages/longherlife Join me in Costa Rica for Optimize Her, a 5-night luxury women's retreat with biohacking, yoga, healing rituals, and longevity workshops—only 2 spots left. Download the non-toxic baby registry guide to reduce toxic exposure and make confident, evidence-informed choices for your family—free. Mindful Meds website and Instagram Get The Mindful Meds Microdosing Guide here LET'S CONNECT: Instagram, TikTok, Facebook Shop my favorite health products Listen on Spotify, Apple Podcasts, YouTube Music  

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Breaking "Wine O'Clock": Psilocybin, Saffron, Microdosing and Upgrading Women's Mental Health with Keegan Downer

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