Breathwork: Asthma Biologic Therapies with Mr. Stephen Shelly (Part 2)

Description This week we speak to Mr Stephen Shelly again about the exciting but sometimes mysterious world of asthma biologics. We speak about the different biologics, going about getting approval to start an asthma biologic, training, and treatment response. We speak about the potential impact that asthma biologics are going to have on the future of asthma (and hopefully COPD!), the cost benefit analysis and the limitations of these new wonder drugs. Chapters 0.42min Intro to Biologics 1.00min Rapid fire round 1.52min Severe asthma & biologic eligibility 3.50min Available biologics 6.50min Which biologic? 7.30min Journey to asthma biologic 13.55min Asthma biologic administration 15.30min Monitoring while on asthma biologic 16.40min Training for asthma biologic admin at home 18.50min Assessing treatment response 21:10min Patient expectations 24:50min Are inhalers still needed? 26:12min Pitfalls in treatment with asthma biologics 28:54min Cost-benefit analysis 31.30min Take-home points Show notes Dupilumab https://www.nejm.org/doi/10.1056/NEJMoa1804092 Mepolizumab https://www.nejm.org/doi/10.1056/NEJMoa1403290 Omalizumab https://www.jacionline.org/article/S0091-6749(01)65945-1/fulltext Benralizumab https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(16)31322-8/abstractTezepelumab https://doi.org/10.1164/rccm.202210-2005OC Difficult to treat asthma (GINA) https://ginasthma.org/wp-content/uploads/2024/11/GINA-Severe-Asthma-Guide-2024-WEB-WMS.pdf Asthma compliance programmes Ireland https://www.rcsi.com/dublin/research-and-innovation/innovation/investors-entrepreneurs-and-spin-outs/phyxiom