Brian Crombie Radio Hour - Epi 1596 - Brain Health, Plasmalogens, and the Future of Medicine with Dayan Goodenowe

On this episode of The Brian Crombie Hour, Brian is joined by Dr. Dayan Goodenowe, neuroscientist, biotech entrepreneur, and founder of Dr. Goodenowe Restorative Health, for a wide-ranging conversation on brain health, aging, and the future of medicine. At the center of the discussion is a little-known but potentially critical class of molecules called plasmalogens — essential components of cell membranes that play a key role in brain function. Dr. Goodenowe explains how declining levels of plasmalogens may be linked to neurodegenerative conditions such as Alzheimer’s, Parkinson’s, ALS, and dementia, and why this area of research could reshape how we understand cognitive decline. The conversation also explores the evolution from nutritional science to therapeutic development, including efforts to advance plasmalogen-based treatments through regulatory pathways, and the challenges of bringing natural compounds into mainstream medical frameworks. Beyond biochemistry, the discussion turns to a broader critique of modern healthcare systems, with Dr. Goodenowe arguing for a shift from reactive “sick care” toward a more restorative model of health — one focused on prevention, cellular repair, and long-term well-being. The episode also examines the lifestyle foundations of health, including nutrition, muscle strength, purpose, and community, and how these factors interact with emerging science to influence longevity and cognitive resilience. A thought-provoking conversation on what it means to truly restore health — and whether the future of medicine lies in prevention rather than treatment.