Building Billion-Pound Outcomes with Jack Edmondson, CIO of Oxford Science Enterprises

Can a university-powered ecosystem become the UK’s next startup superpower? In this episode of Oxford+, host Susannah de Jager sits down with Jack Edmondson, Chief Investment Officer at Oxford Science Enterprises (OSE), to explore the art and challenge of turning world-class research into global impact. With over 20 years in investment and deep ties to the Oxford ecosystem, Jack shares his vision for scaling science-driven startups, the role of co-investors, and how to nurture talent while maintaining commercial rigour. He offers an inside look at OSE’s approach to risk, return, and capital allocation across Life Sciences, Health Tech, and Deep Tech. From robotics and semiconductors to pet health and Alzheimer's care, the conversation spans emerging trends and bold bets. Jack also unpacks why reputation matters in a tightly-knit ecosystem, and why the UK needs high-profile success stories more than policy tweaks. (00:00) - Building Billion-Pound Outcomes with Jack Edmondson, CIO of Oxford Science Enterprises (00:08) - Meet Jack Edmondson: Background and Experience (01:09) - Jack's Role at Oxford Science Enterprises (04:25) - The Structure and Focus of OSE Teams (06:35) - OSE's Achievements and Challenges (08:29) - Navigating the Oxford Ecosystem (12:29) - Investment Strategies and Themes (20:03) - Co-Investment and Capital Strategies (26:15) - The Broader UK Investment Landscape (33:55) - Jack's Personal Journey and Commitment to Oxford (36:00) - Future Vision for OSE (37:58) - Conclusion and Farewell Jack Edmondson: Chief Investment Officer at Oxford Science Enterprises. Former Deputy CIO at Oxford University Endowment Management. Specialist in science-driven venture capital with expertise across institutional investment, private equity, and strategic ecosystem building.Connect with Jack on LinkedInSusannah de Jager: Susannah is a seasoned professional with over 15 years of experience in UK asset management. She has worked closely with industry experts, entrepreneurs, and government officials to shape the conversation around domestic scale-up capital.Connect with Susannah on LinkedInSubscribe to the Oxford+ Newsletter for exclusive content.Oxford+ is hosted by Susannah de Jager and supported by Mishcon de Reya and Oxford North.Produced and edited by Story Ninety-Four in Oxford.