Cabozantinib and Temozolomide in Leiomyosarcoma

In this episode of SARC Talk Journal Club, we review the recent Lancet Oncology phase II trial evaluating the combination of cabozantinib and temozolomide in patients with unresectable or metastatic leiomyosarcoma and other soft tissue sarcomas. Our panel examines the study design, efficacy, safety profile, and clinical implications, discussing whether this combination represents a promising new treatment option and what questions remain for future research.