Calibrate the Signal

This release contains only the music track from Base by Base Episode 313. Song title: Calibrate the SignalOriginal Base by Base episode: 313: Integrating Polygenic Risk Scores and Social Determinants of Health across PopulationsOriginal episode link: https://basebybase.com/episodes/polygenic-risk-sdoh-harmonization Article metadata:Article title: Incorporating polygenic risk scores and social determinants of health across populations: Considerations and best practices in researchJournal: The American Journal of Human GeneticsDOI: 10.1016/j.ajhg.2026.02.007Reference: Cromer SJ, Cobran EK, Iyer HS, Hysong MR, Vargas LB, Smith JL, Konigsberg IR, Bogumil D, Glover L, King G, PRIMED Consortium SDoH Working Group, Lange LA, Patel A, Wojcik G, Raffield L, Conti DV, et al. Incorporating polygenic risk scores and social determinants of health across populations: Considerations and best practices in research. The American Journal of Human Genetics. 2026;113:1–25. https://doi.org/10.1016/j.ajhg.2026.02.007 Lyrics:Verse 1On bright screens we draw the future in lines,A thousand tiny letters trying to speak in time.But the map that fits one skyline in the rain,Can miss the next door heart, call it “risk” in vain. Pre-ChorusWhen the dataset tilts, the compass drifts,And silence in the variables changes what it gives.So we ask the hard questions, name what we can’t see,Build a fairer measure from biology and streets. ChorusCalibrate the signal, don’t crown it as fate,Genes are a rhythm, not a locked gate.Tune it with the context, let the real world in,So prediction becomes a promise—not a spin. Verse 2Alleles shift their patterns, links break and re-tie,Different threads of history under the same sky.And where you live, what you face, what care you can reach,Can bend the odds like gravity, reshaping what we teach. BridgeHarmonize the questions, align the way we count,Test the cause and pathways, trace what they amount.If we share the spotlight, widen every lens,We can stop old bias from wearing science’s name again. Final ChorusCalibrate the signal, don’t crown it as fate,Genes are a rhythm, not a locked gate.Tune it with the context, let the real world in,Make it travel farther—let equity begin.