Can Aging Be Reversed by Science?

Can aging be reversed, or slowed in a meaningful way.This episode covers cellular reprogramming, OSK, Yamanaka factors, epigenetic aging, and the key studies behind the claims.You will hear what the mouse data showed, what chemical reprogramming achieved in human cells, and where the science still has limits.References:Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factorsThe original 2006 iPS paper. It introduced the four factors Oct3/4, Sox2, c-Myc, and Klf4. SourceReprogramming to recover youthful epigenetic information and restore visionThis Nature paper reported that OSK restored youthful DNA methylation patterns, promoted axon regeneration, and reversed vision loss in mouse models. SourceFull text via PubMed Central for the OSK vision paperUseful if you want the full paper without a paywall. SourceChemically induced reprogramming to reverse cellular agingThis paper reported six chemical cocktails that restored a youthful transcript profile in human cells in under a week, without changing cell identity. SourceFull text for the chemical reprogramming paperDirect publisher link to the full study. SourceLoss of epigenetic information as a cause of mammalian agingThe Cell paper that lays out the epigenetic information loss model of aging. SourceClinicalTrials.gov listing, NCT07290244A ClinicalTrials.gov study page connected to this area of research. SourceSupport our work. Make a small donation. This removes any advertisements and help us continue bringing more interesting topics and confronting mainstream narrative on health.Click the Link to support us: https://www.spreaker.com/podcast/foodnourish-deep-dives--6602003/support🤗 Support the show: Become a supporter for just 2€ per month to remove advertisements and help us continue bringing interesting topics while confronting mainstream narratives on health. Support FoodNourish Deep DivesThis episode includes AI-generated content.