Can Erenumab Treat Medication Overuse Headache?

A study published in JAMA Neurology shows that monthly erenumab injections may help treat medication overuse headache (MOH) in people with chronic migraine. While the 140 mg dose was effective for treating MOH, the 70 mg dose did not show a meaningful difference compared to placebo. Molly O'Brien explains in this Migraine Minute News Update. Read More: https://bit.ly/4jCusxk Image Courtesy: JAMA Neurology doi:10.1001/jamaneurol.2024.3043 Transcript: A study published in JAMA Neurology looked at the safety and efficacy of a CGRP monoclonal antibody for treating Medication Overuse Headache in people with chronic migraine. Results show that erenumab– sold under brand name Aimovig- can lead to lasting remission of MOH, reduce the need for pain medication, and improve daily functioning over six months. The study included 584 people with chronic migraine who also had medication overuse headache. At 6 months, 69.1% of those who received 140 mg injections of erenumab monthly no longer met the criteria for medication overuse headache compared to 52.6% of people in the placebo group. It should be noted that the study did not include people who had medication-overuse headache from opioid use.