Can the Brain Understand Itself? The Glories and the Limits of Neuroscience ~ Matthew Cobb

Science has learned much about the brain. But how well do we understand this organ of the mind? Are we even close to cracking the neural code? Is a groundbreaking theory of consciousness just around the corner?In this final episode of the brain science -series, Matthew Cobb takes us on a tour of the story of neuroscience. We meet many colourful characters, but this is not just a history for history’s sake. More importantly, this is a reflection on the increasingly clear limits that brain science is coming up against — limits often left invisible behind the thirst for stories about new discoveries. Enjoy!FACT CHECKINGContrary to the precise phrasing in the episode, a handful of new psychiatric drugs have entered the market recently. The general observation remains well-supported.If you spot an error in this or other episodes, please reach out on ⁠⁠Substack⁠⁠ or via ⁠⁠email⁠⁠.LINKSMatthew Cobb’s book is ⁠The Idea of the Brain: The Past and Future of Neuroscience ⁠For more episodes on the human brain, check ⁠OnHumans.Substack.com/Brain⁠Want to support the show? Join the club at ⁠Patreon.com/OnHumans⁠MENTIONSNames: Matthew Cobb | Galen | Aristotle | Andreas Vesalius | William Harvey | William Shakespeare | Queen Victoria | Karl Marx | Pierre Paul Broca | René Descartes | Eve Marder | David Marr | Francis Crick | Geoffrey Hinton | John Hopfield | Warren McCulloch | Walter Pitts | John von Neumann | Alan Turing | Kenneth Craik | Sir John Eccles | Elon Musk | Nicolaus Copernicus | Galileo Galilei Terms and concepts: recurrent laryngeal nerve | phrenology | localization of function | strokes/aphasia | Broca’s area | plasticity | hemispheric lateralization | corpus callosum | split-brain | consciousness | anesthesia (halothane, etc.) | drugs & neuromodulators | SSRIs | serotonin | dopamine | psychedelics | obster stomatogastric ganglion | three-body-problem | EEG “brainwaves” (gamma, theta, etc.) | David Marr’s levels | neural code | PDP / connectionism | backpropagation | LLMs (e.g. ChatGPT, DeepSeek) | biological plausibility vs engineering | von Neumann architecture | McCulloch–Pitts logical neurons | neural correlates of consciousness (NCC) | “Jennifer Aniston” cells | single-unit recording | connectomics | Human Brain Project | cochlear implants | BCI / robotic arm control | tetraplegia | problem of consciousness | enactive cognition