Case File 06 — Insulin Coma Therapy: Shock Treatment That Became Standard Care

In the 1930s, psychiatrists searching for answers to schizophrenia embraced a radical intervention: insulin coma therapy. By deliberately driving patients into deep hypoglycemic coma—sometimes daily for weeks—physicians believed they could “reset” the brain and disrupt psychosis. Hospitals built specialized insulin wards, and the treatment quickly became standard care despite thin evidence and significant risk. This episode explores how a dangerous shock therapy came to symbolize modern psychiatry, why dramatic case reports overshadowed missing data, and what insulin coma therapy reveals about medicine’s tendency to mistake intensity for effectiveness.For the full written case file, visit thepharmafiles.substack.com. This is a public episode. If you would like to discuss this with other subscribers or get access to bonus episodes, visit thepharmafiles.substack.com