Characteristics and Outcomes of U.S. Children and Adolescents with MIS-C by A. Randolph

Listen as Dr. Adrienne Randolph discusses the epidemiology, clinical characteristics, and outcomes observed in pediatric patients diagnosed with Severe Acute COVID-19 and Multisystem Inflammatory Syndrome in Children (MIS-C). She shares insights into patient features that can help distinguish between these conditions, potentially facilitating the delivery of timely and effective therapies. After this podcast, listeners will be able to: • Contrast the key clinical characteristics of children and adolescents diagnosed with MIS-C versus severe acute COVID-19 • Describe key concerns relating to pediatric COVID-19 vaccine development and pediatric public health measures such as school reopening Articles referenced: • Feldstein LR, Tenforde MW, Friedman KG, et al. Characteristics and Outcomes of US Children and Adolescents With Multisystem Inflammatory Syndrome in Children (MIS-C) Compared With Severe Acute COVID-19. JAMA. 2021;325(11):1074-1087. doi:10.1001/jama.2021.2091 (00:47) • Ferdinands JM, Olsho LE, Agan AA, et al. Effectiveness of influenza vaccine against life-threatening RT-PCR-confirmed influenza illness in US children, 2010-2012. J Infect Dis. 2014;210(5):674-683. doi:10.1093/infdis/jiu185 (01:42) • Feldstein LR, Rose EB, Horwitz SM, et al. Multisystem Inflammatory Syndrome in U.S. Children and Adolescents. N Engl J Med. 2020;383(4):334-346. doi:10.1056/NEJMoa2021680 (02:59) • Truong DT, Trachtenberg FL, Pearson GD, et al. The NHLBI Study on Long-terM OUtcomes after the Multisystem Inflammatory Syndrome In Children (MUSIC): Design and Objectives. Am Heart J. 2022;243:43-53. doi:10.1016/j.ahj.2021.08.003 (11:52) • LaRovere KL, Riggs BJ, Poussaint TY, et al. Neurologic Involvement in Children and Adolescents Hospitalized in the United States for COVID-19 or Multisystem Inflammatory Syndrome. JAMA Neurol. 2021;78(5):536-547. doi:10.1001/jamaneurol.2021.0504 (17:53) Initial publication: March 23, 2021. Speakers: Adrienne Randolph, MD, MSc Senior Associate in Critical Care Medicine Department of Anesthesiology, Critical Care and Pain Medicine Boston Children's Hospital Professor of Anaesthesia Harvard Medical School Jeffrey Burns, MD, MPH Chief and Shapiro Chair, Critical Care Medicine, Executive Chair, International Health Services, Director, OPENPediatrics, Senior Associate in Critical Care Medicine, Department of Anesthesiology, Critical Care and Pain Medicine, Boston Children's Hospital Professor of Anesthesia, Harvard Medical School Citation: Randolph A, Zackin B, Daniel D, Burns JP. Characteristics and Outcomes of Children with MIS-C Compared With Severe Acute COVID-19. 3/2021. Online Podcast. OPENPediatrics. https://soundcloud.com/openpediatrics/characteristics-and-outcomes-of-children-with-mis-c-compared-with-severe-acute-covid-19. This recording is intended to be used as an educational resource for healthcare providers. It is in no way a substitute for the independent decision making and judgment of a qualified healthcare professional. It should not be used to make a diagnosis, or to overrule the advice of a qualified health care provider, nor should it be used to provide advice for emergency medical treatment. Please visit: www.openpediatrics.org