Cholesterol Biosynthesis, Statins, and the Reduction of Plasma LDL

This podcast summarizes the 4 major cellular uses of cholesterol, its biosynthesis, and the regulation of the rate-limiting enzyme HMG CoA reductase by intracellular cholesterol.The podcast further describes the biochemical mechanism involved in the reduction of plasma cholesterol by statin treatment. Ultimately, statins reduce cholesterol synthesis in the liver, which in turn results in the increased gene expression of the LDL receptor in the liver. Consequently, the increased number of LDL receptors on hepatocyte cell surface increases the uptake of LDL from plasma, thus reducing plasma cholesterol. This biochemistry content may be useful to premedical and medical students. Similar content is available at:Check out similar content at: Medbiochem.orgAlso check out the regulation of HMG CoA reductase podcast below:https://youtu.be/FNSr3G6OTBsTwitter @DrAJGhalayini