CIDP: Divyanshu (Div) Dubey, M.B.B.S.
Divyanshu (Div) Dubey, M.B.B.S., describes Mayo Clinic Laboratories' new diagnostic test for CIDP, or chronic inflammatory demyelinating polyneuropathy. The new test detects two antibodies — NF155 and CNTN1 — to enhance diagnosis and guide treatment decis
Episode 168 of the Answers from the Lab podcast, hosted by Mayo Clinic Laboratories, titled "CIDP: Divyanshu (Div) Dubey, M.B.B.S." was published on August 23, 2022 and runs 22 minutes.
August 23, 2022 ·22m · Answers from the Lab
Summary
Divyanshu (Div) Dubey, M.B.B.S., describes Mayo Clinic Laboratories' new diagnostic test for CIDP, or chronic inflammatory demyelinating polyneuropathy. The new test detects two antibodies — NF155 and CNTN1 — to enhance diagnosis and guide treatment decisions. Often misdiagnosed, CIDP is treatable if detected early.
Episode Description
(00:32)
Would you mind telling our listeners a little about yourself and your background?
(01:16)
This evaluation is about CIDP — chronic inflammatory demyelinating polyneuropathy, correct?
(02:16)
Can you give us an overview of what the CIDP evaluation will consist of?
(04:38)
Our standalone test for neurofascin-155 won't change, but will be rolled into this new test along with contactin-1, correct?
(06:41)
This is a very rare disease with subtle clues, so does it make logical sense to pair these two antibodies?
(08:07)
Why did we choose a cell-binding assay over a western blot or other methodology? Is there a reason why contactin-1 is better on CBA methodology?
(09:40)
Can you elaborate on what this phenotype-specific approach means for neurologists, and how it makes their ordering easier?
(11:14)
Even though it's hard to determine exactly what test to order for these patients, testing too broadly can just add to the confusion. Is a narrowed evaluation that answers specific questions more helpful?
(14:42)
Can you give us any clues as to when a physician shouldn't order this test because it's unlikely to be positive?
(15:51)
How does this test drive patient care? A lot of these patients are therapy refractory. What would be the second- or third-level treatment? Is there any oncological association with antibody positivity?
(18:44)
Are there any alternative options for diagnostic answers for this challenging patient population?
(20:44)
What is the key takeaway? What excites you most about this new test launch?
Similar Episodes
Apr 5, 2026 ·6m
Apr 2, 2026 ·5m
Mar 29, 2026 ·7m
Mar 19, 2026 ·5m
Mar 15, 2026 ·7m
Mar 9, 2026 ·12m