CLIC Protein Inhibition Key to Metformin’s Anti-Neoplastic Properties

The Chloride Intracellular Channel 1 (CLIC1) protein appears to hold the key to understanding the anti-proliferative action of metformin, according to laboratory evidence discussed at the AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics held in October 2023, in Boston. At the conference, Michele M. Mazzanti, PhD, from the Department of Bioscience, at Milan University, Italy, reported his group’s recent findings about the possibility of using metformin to reduce glioblastoma mortality. Afterwards he discussed the study and its clinical implications with OncTimes Talk correspondent, Peter Goodwin.