Clinical Management of PCOS

This podcast episode delivers a comprehensive clinical review of polycystic ovary syndrome, emphasizing its modern transition to polyendocrine metabolic ovarian syndrome. Listeners will explore the foundational pathophysiology of the disorder, focusing on gonadotropin dysregulation, intraovarian hyperandrogenism, and tissue-specific insulin resistance. The discussion provides evidence-based strategies for menstrual cycle control and endometrial protection using combined oral contraceptives and intrauterine systems. Additionally, the episode outlines first-line ovulation induction utilizing letrozole, the management of cutaneous hyperandrogenism with anti-androgens, and essential screening protocols to mitigate lifelong cardiometabolic and type two diabetes risks in this patient population.