Clinical Trials Have Opened Doors to COPD Medications

In this week we talk about chronic obstructive pulmonary disease (COPD), a progressive lung condition that restricts airflow due to chronic bronchitis and emphysema, which damages the alveoli. COPD affects around 11% of adults over 30 and is linked to smoking, pollution, and genetic factors. This episode relates COPD to a house with big rooms and narrow doors, making furnishing a challenge, and fives into the mechanisms, symptoms, and treatments for the disease.Share with a friend. Rate, Review, and Subscribe to MedEvidence! Articles to be notified when new episodes are released.Follow us on Social Media:FacebookInstagramTwitterLinkedInTiktokYoutubeFor more great content, including discussions by physicians and clinical research experts, check out the MedEvidence! podcast. www.MedEvidence.comThank you for listening!References:World Health Organization. (January 2024). CA22 Chronic obstructive pulmonary disease. ICD-11 for mortality and morbidity statistics. https://icd.who.int/browse/2025-01/mms/en#133207228Global Initiative for Chronic Obstructive Lung Disease (GOLD). (2025). 2025 Report... Available from: https://goldcopd.orgAdeloye, D., et al. (2015). Global and regional estimates of COPD prevalence... Journal of global health, 5(2). https://pmc.ncbi.nlm.nih.gov/articles/PMC4693508/World Health Organization. (7 August, 2024). The top 10 causes of death. [Website, accessed 17 February, 2025]. https://www.who.int/news-room/fact-sheets/detail/the-top-10-causes-of-deathPatel, M. S., et al. (2019). Anaemia and iron dysregulation... BMJ Open Respiratory Research, 6(1), e000454. https://doi.org/10.1136/bmjresp-2019-000454Chen, W., et al. (2015). Risk of cardiovascular comorbidity in patients with chronic obstructive pulmonary disease... The Lancet Respiratory Medicine, 3(8), 631-639.https://www.thelancet.com/journals/lanres/article/PIIS2213-2600(15)00241-6/abstractCrisan, L., et al. (2019). Karma of cardiovascular disease risk factors for prevention and management of major cardiovascular events... Frontiers in cardiovascular medicine, 6, 79. https://pubmed.ncbi.nlm.nih.gov/31294030/Curkendall, S. M., et al. (2006). Cardiovascular disease in patients with chronic obstructive pulmonary disease, Saskatchewan Canada... Annals of epidemiology, 16(1), 63-70. https://pubmed.ncbi.nlm.nih.gov/16039877/Stone, I. S., et al. (2016). Lung deflation and cardiovascular structure and function in chronic obstructive pulmonary disease... American journal of respiratory and critical care medicine, 193(7), 717-726. https://doi.org/10.1164/rccm.201508-1647OCDivo, M. J., et al. (2020). Metabolic and cardiorespiratory effects of decreasing lung hyperinflation with budesonide/formoterol in COPD... Respiratory Research, 21, 1-9. https://pubmed.ncbi.nlm.nih.gov/31959167/Vestbo, J., et al. (2016). Fluticasone furoate and vilanterol and survival in chronic obstructive pulmonary disease...(SUMMIT)... The Lancet, 387(10030), 1817-1826. https://www.sciencedirect.com/science/article/pii/S0140673616300691Sin, D. D., et al. (2004). Effects of fluticasone on systemic markers of inflammation ... American journal of respiratory and critical care medicine, 170(7), 760-765. https://pubmed.ncbi.nlm.nih.gov/15229100/Rabe, K. F., et al. (2020). Triple inhaled therapy at two glucocorticoid doses in moderate-to-very-severe COPD. New England Journal of Medicine, 383(1), 35-48. https://www.nejm.org/doi/full/10.1056/NEJMoa1916046Share with a friend. Rate, Review, and Subscribe to MedEvidence! Articles to be notified when new episodes are released.Follow us on Social Media:FacebookInstagramTwitterLinkedInTiktokYoutubeFor more great content, including discussions by physicians and clinical research experts, check out the MedEvidence! Podcast and MedEvidence.comThank you for listening!