Clinics in Liver Disease

A comprehensive overview of the pathophysiology of liver fibrosis and cirrhosis, emphasizing the dynamic and potentially reversible nature of the disease. They thoroughly examine the cellular and molecular mechanisms driving fibrogenesis, focusing heavily on the pivotal role of Hepatic Stellate Cells (HSCs) and their activation by factors like growth factors (e.g., TGF-β1, PDGF), cytokines, and reactive oxygen/nitrogen species. Furthermore, the texts discuss genetic determinants of fibrosis susceptibility using mouse models and human association studies, alongside the involvement of the immune system and the renin–angiotensin system as key mediators. Finally, the sources evaluate various diagnostic tools (both invasive and non-invasive) for assessing fibrosis severity and progression, and explore numerous potential therapeutic targets aimed at inhibiting HSC activation or promoting fibrosis regression.Get the Book now from Amazon:https://www.amazon.com/Endoscopy-Liver-Disease-Issue-Clinics/dp/1437719147?&linkCode=ll1&tag=cvthunderx-20&linkId=d8a687b0c7fb615ea2d4d5b39753f9e9&language=en_US&ref_=as_li_ss_tlYou can listen and download our episodes for free on more than 10 different platforms:https://linktr.ee/pharmacy_simpleProduced by:https://www.podcaistudio.com/