Colleen Cutcliffe, PhD: Microbiome Science, GLP-1, and Next-Gen Probiotics That Actually Deliver

Colleen Cutcliffe, PhD, co-founder and CEO of Pendulum, joins us to demystify the microbiome and explain what “next-generation probiotics” really are. Colleen shares how DNA sequencing opened the door to mapping the gut, why Akkermansia is a keystone strain for gut integrity and GLP-1 stimulation, and how Pendulum approaches clinical evidence with randomized, double-blind trials. She walks through what to look for on labels (enteric coating and time-delayed release), when and why people become depleted in key strains, and the real-world use cases for metabolic health, GI stability, travel, stress, aging, and sport performance.You’ll also hear the personal story that fueled Pendulum’s mission, how food choices like high-polyphenol and high-fiber options feed a healthier microbiome, and Colleen’s take on pairing natural tools with medications when appropriate. We wrap with leadership lessons, building trust in a crowded supplement market, and one big misconception about gut health she hopes more people understand.Takeaways:• Next-gen probiotics target more than bloating• Akkermansia supports gut lining, tight junctions, and GLP-1• Delivery tech matters as much as what’s inside• Polyphenols and fiber are powerful prebiotics• Evidence and education build lasting trustTune in to learn how smarter microbiome choices can support metabolism, energy, and overall health.