Could Your Heart Be at Risk Even If You Feel Healthy? with JD Enright

Send us Fan MailA “zero calcium score” sounds like a clean bill of health, but JD Enright learnt the hard way that it can still hide dangerous coronary artery disease. After five years of high-end executive screening and a mountain of reassuring results, one focused consultation using advanced imaging showed stage two cardiovascular disease and a heavy burden of soft plaque, the kind most associated with plaque rupture and sudden heart attack or stroke. That moment became the spark for Clear Cardio’s mission: move cardiology from reacting to symptoms to preventing the event in the first place. We unpack what breaks in the traditional pathway when you feel fine: why ECGs and treadmill stress tests often miss the real problem, why calcium scoring can be falsely comforting, and how plaque actually builds inside the artery wall. JD explains plaque rupture in clear, practical terms, then walks through how a cardiac CT angiogram (CCTA) paired with AI plaque analysis can map plaque type, quantify burden, and show exactly where risk sits, giving patients a way to track progress rather than guess. The conversation also gets honest about incentives. Insurance often covers late-stage procedures but not early prevention, which makes education and direct-to-consumer access essential. We talk about resistance from parts of the system that profit from interventional volume, why Clear Cardio stays tightly focused on one problem, and how YouTube and content-led marketing are driving patient demand. If you care about preventive cardiology, heart attack prevention, stroke prevention, and the future of AI in healthcare, press play, then subscribe, share with a friend, and leave a review. What would it take for prevention to become the default?Guest BiographyJD Enright is the CEO and Co-Founder of ClearCardio, a preventative cardiology organisation dedicated to identifying and reducing cardiovascular risk before symptoms develop. With a background spanning engineering, biotechnology, pharmaceuticals, strategic acquisitions and technology commercialisation, JD has led global business growth initiatives across multiple industries before founding ClearCardio alongside preventative cardiologist Dr John Osborne. Following his own unexpected diagnosis of significant coronary artery disease despite extensive executive health screening, JD set out to build a business that combines advanced coronary CT angiography (CCTA), AI-powered plaque analysis and personalised prevention strategies to help patients detect and manage cardiovascular disease earlier. Today, he leads ClearCardio's mission to transform cardiovascular care through innovation, education and proactive prevention.LinksWebsite: https://www.clearcardio.comLinkedIn: https://www.linkedin.com/in/jdenright/Subscribe on SubstackVoices in Health and Wellness is published on Substack, as part of The Diagnostician. Every episode lands there with written notes and reflections you won't find in the podcast feed. Free to subscribe.👉 https://thediagnostician.substack.com/s/voices-in-health-and-wellnessAbout the podcastVoices in Health and Wellness features conversations at the intersection of medicine, lifestyle, and human potential, with clinicians, scientists, and thinkers shaping the future of care.About Dr Andrew GreenlandUK-based medical doctor and founder of Greenland Medical, specialising in Integrative and Functional Medicine. Trained in both conventional and root-cause approaches, Andrew helps people optimise health, performance, and longevity, with a focus on cognitive resilience and healthy ageing.