EPISODE · Dec 10, 2025 · 37 MIN
Crypto's Killer App?
from a16z crypto show · host Sean Neville, Zach Abrams, Robert Hackett
with @zcabrams @psneville @rhackettIn this episode, Robert Hackett sits down with Sean Neville, cofounder of Circle and co-creator of the USDC stablecoin, and Zach Abrams, founder of Bridge (now part of Stripe), for a deep dive into the real story behind stablecoins, finding product-market fit, and the future of payments infrastructure.They explore the earliest days of USDC — when stablecoins were far from obvious and regulatory frameworks didn’t exist. Sean shares how his conviction in “money running at internet speed” helped shape a multibillion-dollar asset. Zach recounts Bridge’s pivot from NFTs to stablecoin infrastructure — and how his business has changed since joining Stripe.Together, they break down:Why stablecoins are having their moment nowWhat counts as product-market fit (and why founders rarely “feel” it)The challenges of building crypto and AI products within heavily regulated environmentsWhy new base-layer chains like Arc, Tempo, and others may be neededHow decentralization, liquidity moats, and interoperability will define the next decade of blockchain adoptionWhat the future of programmable money and AI-driven financial workflows looks likeWhether you’re a founder, a crypto-curious builder, or someone trying to understand where global payments are headed, this conversation — originally recorded live at our recent a16z crypto Founders Summit — offers insights from two operators at the center of an industry-defining transformation.Guests:• Sean Neville — Cofounder, Circle; CEO and cofounder, Catena• Zach Abrams — Founder and CEO, Bridge (acquired by Stripe)Highlights:01:26 — Origins of USDC02:44 — Why stablecoins are having their moment now04:14 — Circle’s early product experiments06:19— Surviving crypto cycles07:35 — Bridge: From NFT payments to stablecoins08:58 — What product-market fit actually feels like20:02 — Inevitability and the founder vs. employer mindset20:58 — Why Bridge joined Stripe26:18 — How AI changes company building29:38 — What students should study now30:27 — Why new payment chains (Tempo & Arc)?35:55 — Decentralization as imperativeFollow a16z crypto on...X: https://x.com/a16zcryptoLinkedIn: https://www.linkedin.com/showcase/a16zcrypto/posts/Spotify: https://open.spotify.com/show/7pMZvsNXEnb0CYcPiDQywEApple Podcasts: https://podcasts.apple.com/us/podcast/web3-with-a16z-crypto/id1622312549Youtube: https://www.youtube.com/@a16zcrypto📩 Subscribe for more industry reports, trend updates, news analysis, builder guides, and other resources: https://a16zcrypto.substack.com/subscribe/ 🎙️ Like, subscribe, comment, share the show: https://a16zcrypto.com/posts/podcast/ ***As always, none of the following should be taken as investment, business, legal, or tax advice. Please see a16z.com/disclosures for more important information, including a link to a list of our investments. Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.
What this episode covers
Sean Neville (cofounder of Circle and co-creator of USDC) and Zach Abrams (founder of Bridge, now part of Stripe) unpack the real story behind stablecoins and the future of internet-native money. They share lessons on finding product-market fit, surviving early chaos, and building financial infrastructure at planetary scale.
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Crypto's Killer App?
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