EPISODE · Dec 19, 2025 · 31 MIN
Cyber Defense for Generative AI
from The Macro AI Podcast · host The AI Guides - Gary Sloper & Scott Bryan
In this flagship episode, Gary Sloper and Scott Bryan deliver the most comprehensive executive briefing to date on Cyber Defense for Generative AI—a real-world, board-level conversation every business and technology leader needs to hear. Generative AI is transforming how enterprises operate, but it also introduces an entirely new attack surface. Traditional cybersecurity models were never built for systems that reason, take action, integrate with sensitive data, and can be manipulated through language alone. This episode breaks down what that means for your business, your customers, and your risk posture. Gary and Scott guide you through the full lifecycle of securing GenAI: how these systems fail, where attackers are striking today, how enterprise architectures introduce new vulnerabilities, what frameworks (like NIST’s AI RMF) actually matter, and how leaders should build a modern defense-in-depth strategy tailored specifically for LLMs, RAG pipelines, and AI agents. You’ll hear detailed insight into prompt injection, jailbreaks, data poisoning, insecure output handling, RAG access control, observability, vendor risk, and the organizational operating models required to govern AI safely. The episode closes with a clear 30/90/365-day executive roadmap to help any organization move from experimentation to secure, governed AI at scale. If you’re a CIO, CISO, CTO, head of data/AI, product leader, or board member tasked with understanding the true cyber risks of GenAI, this episode is your playbook. Send a Text to the AI Guides on the show!About your AI GuidesGary Sloperhttps://www.linkedin.com/in/gsloper/Scott Bryanhttps://www.linkedin.com/in/scottjbryan/ Macro AI Website: https://www.macroaipodcast.com/Macro AI LinkedIn Page: https://www.linkedin.com/company/macro-ai-podcast/Gary's Free AI Readiness Assessment:https://macronetservices.com/events/the-comprehensive-guide-to-ai-readinessScott's Content & Bloghttps://www.macronomics.ai/blog
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Cyber Defense for Generative AI
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