Dave Asprey: How Can You Upgrade Your Brain, Body and Longevity

Some biohacking gets sold as a shortcut, hacking the right levers and you'll coast to 180. But the most important thing learned in a lifetime of measuring everything is the one thing that never shows up on a blood panel.I sat down with Dave Asprey, the entrepreneur who named and organized "biohacking," founder of Bulletproof, Danger Coffee, Upgrade Labs, and 40 Years of Zen, and four-time New York Times bestselling author. Join me to talk about what it really takes to build a body and mind that holds up for the long run. We move from data-driven protocols to the parts most people skip: parenting without reactivity, forgiveness, surrender, and knowing when your intuition is telling you something your spreadsheet can't. Dave opens up about his autism diagnosis, losing a $100M business, and why he believes mitochondrial function shapes not just your energy but your capacity to think clearly and connect. Whether you're a parent, a founder, or just trying to stay sharp as the years add up, this one frames longevity around your character, not only your bloodwork.What we explore:- How to raise resilient kids by modeling non-reactivity and clear boundaries.- Why intuition-first decisions, validated by data, beat leading with data alone.- What surrender really means, and the lesson behind a $100M loss.- How mitochondrial function connects energy to focus, mood, and clear thinking.- Why deliberate discomfort is an underrated tool for building durability at any age.Chapters:00:00 The Godfather of Biohacking Explains It All02:20 How to Parent Teens Without Reactivity10:23 How Biohacking Goes Beyond the Body11:25 Can You Actually Hack Consciousness?24:11 What Actually Helps Kids on the Spectrum30:37 Why Deliberate Discomfort Makes You Stronger33:42 The Surrender Lesson From a $100M Loss47:47 Why 80% of Longevity Is Fear of Death50:29 The Case for Living to 180 Years52:47 Why Personal Sovereignty Matters Most53:57 How Trauma Silently Drains Your Energy57:06 The 5 F-Words Your Body Runs On01:05:35 How to Actually Screen for Cancer Early01:19:14 Travel Hacks Every Frequent Flyer Needs01:42:52 The Peptides Behind His Longevity Stack01:47:21 Why He's Hopeful About Human PotentialAbout Dave Asprey:Dave Asprey is the entrepreneur widely credited as the "father of biohacking" and the founder of Bulletproof, Danger Coffee, Upgrade Labs, and 40 Years of Zen. He's a four-time New York Times bestselling author and host of the top-ranked podcast The Human Upgrade, known for blending rigorous, data-driven experimentation with a broader philosophy about human potential.Connect with Dave Asprey: Website: https://daveasprey.comYouTube: https://www.youtube.com/c/DaveAspreyBPRInstagram: https://www.instagram.com/dave.aspreyGet the 4x New York Best Selling Book:👉https://daveasprey.com/books–The Gabby Reece ShowThis is where I have real conversations with the people I find most worth listening to: scientists, athletes, coaches, parents, and thinkers who are doing the hard work of building a life that holds up over time. No hacks. No quick fixes. Just honest, practical conversations about performance, longevity, relationships, and what it actually takes to show up well at every age.If you are here, you probably already know that health is not a destination. It is how you live. I am glad you are along for it.Connect with Gabby Reece:Instagram: https://www.instagram.com/gabbyreece/TikTok: https://www.tiktok.com/@gabbyreeceofficialWebsite: https://gabriellereece.com This is a public episode. If you would like to discuss this with other subscribers or get access to bonus episodes, visit thegabbyreeceshow.substack.com