DDT, Atopic Dermatitis, and the Consequences of Overreaction

This week we explore atopic dermatitis, oftne called eczema. This skin condition is common, long lasting, and can have serious effects on mental health and relationships. We explore who gets it, how it works in the body, and what treatments are available and on the horizon.References:Fisher G. Presentation speech by professor G. Fischer, member of the staff of professors of the Royal Caroline Institute. Nobel Lectures, Physiology or Medicine 1942-1962. Amsterdam: Elsevier Publishing Company; 1964. Available at https://www.nobelprize.org/prizes/medicine/1948/ceremony-speech/Jarman WM, Ballschmiter K. From coal to DDT: the history of the development of the pesticide DDT from synthetic dyes till Silent Spring. Endeavour. 2012 Dec 1;36(4):131-42. https://doi.org/10.1016/j.endeavour.2012.10.003Harada T, Takeda M, Kojima S, Tomiyama N. Toxicity and carcinogenicity of dichlorodiphenyltrichloroethane (DDT). Toxicological research. 2016 Jan;32(1):21-33. https://doi.org/10.5487/TR.2016.32.1.021Beard J, Australian Rural Health Research Collaboration. DDT and human health. Science of the total environment. 2006 Feb 15;355(1-3):78-89. https://doi.org/10.1016/j.scitotenv.2005.02.022Wollenberg A, Barbarot S, Bieber T, Christen‐Zaech S, Deleuran M, Fink‐Wagner A, Gieler U, Girolomoni G, Lau S, Muraro A, Czarnecka‐Operacz M. Consensus‐based European guidelines for treatment of atopic eczema (atopic dermatitis) in adults and children: part I. Journal of the European Academy of Dermatology and Venereology. 2018 May;32(5):657-82. https://doi.org/10.1111/jdv.14891Fuxench ZC, Block JK, Boguniewicz M, Boyle J, Fonacier L, Gelfand JM, Grayson MH, Margolis DJ, Mitchell L, Silverberg JI, Schwartz L. Atopic dermatitis in America study: a cross-sectional study examining the prevalence and disease burden of atopic dermatitis in the US adult population. Journal of Investigative Dermatology. 2019 Mar 1;139(3):583-90. https://doi.org/10.1016/j.jid.2018.08.028Zuberbier T, Orlow SJ, Paller AS, Taïeb A, Allen R, Hernanz-Hermosa JM, Ocampo-Candiani J, Cox M, Langeraar J, Simon JC. Patient perspectives on the management of atopic dermatitis. Journal of Allergy and Clinical Immunology. 2006 Jul 1;118(1):226-32. https://www.sciencedirect.com/science/article/abs/pii/S0091674906004507Yang L, Fu J, Zhou Y. Research progress in atopic march. Frontiers in immunology. 2020 Aug 27;11:1907. https://doi.org/10.3389/fimmu.2020.01907Locksley RM. Asthma and allergic inflammation. Cell. 2010 Mar 19;140(6):777-83. https://www.cell.com/cell/fulltext/S0092-8674(10)00240-0Share with a friend. Rate, Review, and Subscribe to MedEvidence! Articles to be notified when new episodes are released.Follow us on Social Media:FacebookInstagramTwitterLinkedInTiktokYoutubeFor more great content, including discussions by physicians and clinical research experts, check out the MedEvidence! Podcast and MedEvidence.comThank you for listening!