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Deciphering the Molecular Underpinning of Ulcerative Colitis Associated Colorectal Cancer episode artwork

EPISODE · Jun 10, 2021 · 14 MIN

Deciphering the Molecular Underpinning of Ulcerative Colitis Associated Colorectal Cancer

from Springer Nature · host Springer Nature

Dr. Daniela Hirsch, from the Institute of Pathology at the University of Heidelberg in Germany, discusses her findings on the molecular alterations associated with colorectal cancer in the setting of Ulcerative Colitis. Using aCGH, a 48 gene panel and MSI analysis and IHC for TP53, the author and her team revealed high rate of TP53 mutations and gains in chromosome 5p in these predominantly Microsatellite stable tumors. Phylogenic clues about ontogenesis and field effect are discerned from synchronous tumors. Associated article: Molecular characterization of ulcerative colitis-associated colorectal carcinomas https://www.nature.com/articles/s41379-020-00722-5

What this episode covers

Dr. Daniela Hirsch, from the Institute of Pathology at the University of Heidelberg in Germany, discusses her findings on the molecular alterations associated with colorectal cancer in the setting of Ulcerative Colitis. Using aCGH, a 48 gene panel and MSI analysis and IHC for TP53, the author and her team revealed high rate of TP53 mutations and gains in chromosome 5p in these predominantly Microsatellite stable tumors. Phylogenic clues about ontogenesis and field effect are discerned from synchronous tumors. Associated article: Molecular characterization of ulcerative colitis-associated colorectal carcinomas https://www.nature.com/articles/s41379-020-00722-5

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Deciphering the Molecular Underpinning of Ulcerative Colitis Associated Colorectal Cancer

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How long is this episode of Springer Nature?

This episode is 14 minutes long.

When was this Springer Nature episode published?

This episode was published on June 10, 2021.

What is this episode about?

Dr. Daniela Hirsch, from the Institute of Pathology at the University of Heidelberg in Germany, discusses her findings on the molecular alterations associated with colorectal cancer in the setting of Ulcerative Colitis. Using aCGH, a 48 gene panel...

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