DECODING DEXAMETHASONE'S ANTIEMETIC EFFECT (MECHANISM EXPLAINED) │ EP112

Welcome to the Atomic Anesthesia podcast hosted by CRNA professor Dr. Rhea Temmermand and Co-Founder Sachi Lord. On this show, you'll hear clear, clinically grounded discussions designed for nurse anesthesia residents and CRNAs who want to feel more confident in complex pharmacology, physiology, and real-world anesthesia decision-making.Want more content like this? Become a member of our learning platform: http://atomicanesthesia.comIn this episode:Exactly how PONV happens in the brain, no vague "vomiting center" hand wavingAll 5 real mechanisms behind how dexamethasone actually stops nausea and vomitingThe practical dosing, timing, and combination strategy that gets the best PONV preventionReferences:Chu CC, Hsing CH, Shieh JP, Chien CC, Ho CM, Wang JJ. The cellular mechanisms of the antiemetic action of dexamethasone and related glucocorticoids against vomiting. Eur J Pharmacol. 2014;722:48-54.Horn CC, Wallisch WJ, Homanics GE, Williams JP. Pathophysiological and neurochemical mechanisms of postoperative nausea and vomiting. Eur J Pharmacol. 2014;722:55-66.Ho CM, Wu HL, Ho ST, Wang JJ. Dexamethasone prevents postoperative nausea and vomiting: benefit versus risk. Acta Anaesthesiol Taiwan. 2011;49(3):100-104.💜 FREE DOWNLOADS: Grab your copy of customized study plans & worksheets.SEE/NCE Study Plan — a structured, week-by-week plan to pass your boardsNon-Opioid Pharmacology Cheat Sheet — every non-opioid analgesic you need to know, one pageGPCR Cheat Sheet — G-protein coupled receptors decoded for anesthesia💜 CONNECT: 📥 Email questions, comments or topic suggestions to Rhea or Sachi at [email protected], follow us on social media, and sign up for our newsletter.Mentioned in this episode:💜 PARTNERS: The Incomologists®https://theincomologists.com/ You work hard caring for others—let us take care of you. Whether you’re a W-2 employee or transitioning to a 1099 role, we understand the unique challenges healthcare professionals face, from insurance coverage to financial planning. That’s where we step in. Like you, we are a team of healthcare providers who understand your needs and help you find tailored insurance plans and financial strategies without the hassle or pressure. And we’re a partner you can rely on, today and in the future. We evaluate all available options and resources in the market to protect our clients, so contact us, and we’ll get started! - Jake Bevilacqua, CRNA ([email protected])