Deep Dive 2: Sex Differences in Alzheimer's Disease: Reproductive Health

This episode explores how reproductive ageing and biological sex influence Alzheimer's disease risk. Rachel Buckley discusses menopause, hormonal changes, genetic factors such as the X chromosome, and emerging evidence showing differences in tau accumulation between women and men. Timestamps: 00:00:55:03 – Menopause and Alzheimer's disease 00:04:51:11 – X chromosome in Alzheimer's disease 00:08:29:01 – Tau accumulation in women 00:10:43:09 – Hormone replacement therapy 00:14:22:24 – The sweet spot with hormone therapy