Dennis DePue: The Murder, the Phone Call, and the Disappearance (E170)

In April 1990, Dennis DePue called police to report that his estranged wife, Marilynn DePue, had disappeared after the couple met to discuss their divorce. At first, it appeared to be another missing persons investigation but detectives soon uncovered evidence that transformed the case into a nationwide manhunt.As Dennis fled across multiple states, investigators pieced together a timeline of deception, violence, and desperation. The pursuit ultimately ended with a dramatic confrontation, but the case would gain lasting notoriety after inspiring one of the most unforgettable segments ever featured on Unsolved Mysteries.More than three decades later, the story remains a powerful example of how domestic violence can escalate into tragedy and how one phone call concealed a far darker reality.