Derm: Bowen's Disease: Free MSRA Podcast

⚕️ FREE MSRA PODCAST – Bowen’s Disease🎧 A clear, high-yield breakdown of this precancerous skin condition (SCC in situ) – perfect for exam prep and real-life clinical scenarios.🧠 Key Learning Points📌 Definition• Bowen’s disease is squamous cell carcinoma in situ, a form of non-invasive skin cancer where abnormal keratinocytes are confined to the epidermis.📌 Causes & Risk Factors• UV radiation (sunlight, sunbeds, past radiotherapy)• HPV infection – especially HPV-16• Immunosuppression – e.g. organ transplant, HIV• Arsenic exposure• Chronic skin inflammation or trauma🧠 Mnemonic: “SHIP-A” – Sunlight, HPV, Immunosuppression, Past skin trauma, Arsenic📌 Pathophysiology• DNA damage in epidermal squamous cells → abnormal proliferation• Growth remains intraepidermal• Basement membrane stays intact – key defining feature• Histologically: full-thickness atypia, disordered architecture, abnormal keratinocytes📌 Symptoms• Red, scaly, well-demarcated plaques – often slow-growing• Itchy or asymptomatic• Commonly found on sun-exposed areas (face, scalp, hands)• In the UK, often affects lower limbs• Genital lesions = Erythroplasia of Queyrat🧠 Think: “Slow, Scaly, Single Patch”📌 Differential Diagnosis• Actinic keratosis• Psoriasis, eczema, seborrhoeic dermatitis• Superficial BCC, melanoma• Cutaneous T-cell lymphoma• Lichen planus📌 Diagnosis• Skin biopsy is essentialConfirms diagnosisExcludes invasive SCC• Can be excisional or punch biopsy• Dermoscopy may assist visually🧠 Look for: full-thickness epidermal atypia, intact basement membrane📌 Management• Topical: 5-fluorouracil (5-FU), imiquimod• Cryotherapy, curettage + cautery• Photodynamic therapy (PDT) – for larger/multiple lesions• Surgical excision – especially for resistant lesions• Mohs surgery – for high-risk or recurrent cases• Radiotherapy – for inoperable cases• Follow-up for recurrence or new lesions📌 Complications• Progression to invasive squamous cell carcinoma (approx. 3–10%)• Recurrence post-treatment• Cosmetic impact (e.g. scarring, pigmentation)📌 Prognosis• Excellent if treated• Lesions rarely metastasise due to non-invasiveness• Genital lesions (Erythroplasia of Queyrat) have higher risk of progression• Long-term risk of other non-melanoma skin cancers (NMSCs) – due to cumulative UV damage📎 More MSRA Resources for Bowen’s Disease📝 Revision Notes:https://www.passthemsra.com/topic/bowens-disease-revision-notes/🧠 Flashcards:https://www.passthemsra.com/topic/bowens-disease-flashcards/💬 Accordion Q&A Notes:https://www.passthemsra.com/topic/bowens-disease-accordion-qa-notes/🚀 Rapid Quiz:https://www.passthemsra.com/topic/bowens-disease-rapid-quiz/🧪 Topic Quiz:https://www.passthemsra.com/quizzes/bowens-disease/🎓 Full Course:https://www.passthemsra.com/courses/dermatology-for-the-msra/📣 All resources are part of the Dermatology for the MSRA course athttps://www.passthemsra.com – your high-yield, NICE-based revision hub 🔍Hashtags#MSRA #MSRARevisionNotes #MSRATextbook #MSRAQuiz #MSRAQuestionBank #MSRAFlashcards #MSRAQANotes #MSRAAccordions #MultiSpecialityRecruitmentAssessment #MSRAOnlineRevision #MSRARevisionWebsite #BowensDisease #Dermatology #SCCinSitu #ErythroplasiaOfQueyrat #NonMelanomaSkinCancer