Do I have to wait for a callus to go away before I can run?

I just saw a woman with an extremely painful callus on the bottom of her foot. She got a type of callus doctors call an "intractable plantar keratosis." When you get one of these calluses, it turns into a tiny rock hard callus embedded deep in the skin on the bottom of the foot. It hurts. It's like having a little rock taped to your foot. In theory, you can start running as soon as the callus is removed.  But the real question is whether or not running right away will increase the probability of getting the same callus again.  Do I have to wait for my callus to go away before I can run?  Well, that's a great question and that's what we're talking about today on the Doc On The Run Podcast.