Does Testosterone Replacement Therapy Cause Prostate Cancer?

Evidence Cited In This Episode1. Prostate Safety and the TRAVERSE Trial (Randomized Clinical Trial)Bhasin et al. Prostate Safety Events During Testosterone Replacement Therapy in Men With Hypogonadism: A Randomized Clinical Trial — JAMA Network Open (TRAVERSE).https://jamanetwork.com/journals/jamanetworkopen/fullarticle/28132932. Prostate Tissue Effects of TRTMarks et al., Effect of Testosterone Replacement Therapy on Prostate Tissue in Aging Men — JAMA 2006 (Demonstrates minimal change in prostate tissue androgen concentrations with TRT).https://www.hormonebalance.org/images/documents/Marks%2006%20Testosterone%20and%20Prostate%20cancer%20JAMA.pdf3. Prostate Risk and Monitoring During TRT (Review)Academic review of TRAVERSE and other randomized trials summarizing prostate safety outcomes and the importance of monitoring during TRT.https://academic.oup.com/jcem/article/109/8/1975/76754614. Harvard Health Commentary on TRT & Prostate Cancer RiskHarvard Health Publishing: Appropriate use of testosterone therapy does not appear to raise prostate cancer risk (comments on randomized evidence showing no increased risk over ~3 years).https://www.health.harvard.edu/mens-health/appropriate-use-of-testosterone-therapy-does-not-appear-to-raise-prostate-cancer-risk