Dr. Dipak Panigrahy "Battling Cancer Softly: SPMs, Tumor Debris Clearance & Resolution in Cancer Therapy"

Episode 8 Dr. Dipak Panigrahy" Battling Cancer Softly: SPMs, Tumor Debris Clearance & Resolution in Cancer Therapy"Welcome to the SPM Podcast, the podcastabout Specialized Pro-Resolving Mediators. Subscribe, leave a comment, and share this episode with anyone interested in cancer biology, inflammation resolution, and innovativeapproaches to oncology. Episode Summary: In this eye-opening episode, we welcome Dr.Dipak Panigrahy, a pioneering researcher exploring the role of Specialized Pro-ResolvingMediators (SPMs) in cancer.Dr. Panigrahy explains how conventional cancertreatments like chemotherapy and surgery, while killing tumor cells, can generate tumor debris killing tumor cells, can generate tumor debris that fuels inflammation and promotes cancer recurrence and metastasis.He discusses how SPMs (such as resolvins,maresins, and protectins) actively resolve this inflammation, enhance the clearance of tumor debris by macrophages, reprogram the tumor microenvironment, and suppress cancer progression without immunosuppression.The conversation highlights the paradigm shift from solely destroying cancer cells to also promoting active resolution of the resulting inflammation for better long-term outcomes. Guest Bio: Dr. Dipak Panigrahy, MD, is an Assistant Professor of Pathology at Harvard Medical School and Beth Israel Deaconess Medical Center (BIDMC) in Boston, where he leads a research laboratory in the Center for Vascular Biology Research.His groundbreaking work focuses on the intersection of inflammation, lipid mediators, and cancer.Dr. Panigrahy investigates how Specialized Pro- Resolving Mediators (SPMs) can be harnessed to mitigate cancer-related inflammation, cleartherapy-induced tumor debris, reduce metastasis, and improve the efficacy of conventional cancer treatments.He has collaborated extensively with SPM pioneer Dr. Charles Serhan and is a leading voice in resolution biology applied to oncology.Resources Mentioned: Key Papers:Preoperative stimulation of resolution and inflammation blockade eradicates micrometastases Journal of Clinical Investigation 2019 https://www.jci.org/articles/view/127282 Aspirin-triggered proresolving mediators stimulate resolution in cancer PNAS, 2019 https://www.pnas.org/doi/10.1073/ pnas.1804000116Exploring the unique role of specialized pro-resolving mediators in cancer therapeutics Prostaglandins & Other Lipid Mediators, 2024https://pubmed.ncbi.nlm.nih.gov/39722403/ Specialized Pro-Resolving Mediators Mitigate Cancer-Related Inflammation Frontiers in Immunology, 2021 https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2021.702785/fullAdditional Resources: Metagenics Institute Interview: Impact of SPMs on Tumor Size and Growth https://www.metagenicsinstitute.com/video/spms-impact-tumor-growth/ Panigrahy Lab Beth Israel Deaconess Medical Center https://research.bidmc.org/dipak-panigrahy/ research