Dr. Edward Calabrese on Hormesis

In this episode of Death Clock, Brent sits down with Dr. Edward Calabrese, the scientist who helped pioneer the modern understanding of hormesis: the idea that low doses of stress can trigger powerful adaptive responses that make the body more resilient. The conversation explores how hormesis shows up in exercise, fasting, heat exposure, cold exposure, and even surprising areas like radiation and toxicology. Along the way, Calabrese shares the lifestyle habits he has followed for decades, from daily exercise and intermittent fasting to an unconventional one-meal-a-day routine, and explains why he believes strategic stress may be one of the most underappreciated tools for improving health and longevity. He's a fascinating guest, hope you enjoy.