Dr. Iain P. Hargreaves: CoQ10, Mitochondrial Dysfunction, Deficiency Diseases and Clinical Considerations

Coenzyme Q10 has established use across both primary and secondary deficiency diseases. In this episode, Dr. Iain P. Hargreaves, PhD, an eminent scientist working on CoQ10, walks us through its history, functions, his work looking at blood brain barrier transport, clinical considerations around testing and supplementation, and where research is going in the future.   About our guest:   Dr. Iain P. Hargreaves, PhD is Senior Lecturer in Clinical Biochemistry / Honorary Consultant Clinical Scientist at the Neurometabolic Unit, National Hospital, Queen Square, London, UK School of Pharmacy, Liverpool John Moores University, Liverpool, UK.   Following his completion of a PhD in biochemistry at Liverpool University, UK he worked for Prof. Simon Heales and Dr. John Land at the Institute of Neurology, University College of London, London, UK where he was involved in the establishment of the Neurometabolic Unit which specialises in the diagnosis of metabolic disease, especially mitochondrial and neurotransmitter disorders.   Dr Hargreaves worked in the Neurometabolic Unit for 21 years until he left to take up a lecturing position in biochemistry/clinical biochemistry at Liverpool John Moores University, Liverpool, UK. Dr Hargreaves has retained an honorary consultant clinical scientist and senior lecturer position within the Neurometabolic Unit and Institute of Neurology, respectively and is still actively involved in the mitochondrial diagnostic service.   Dr Hargreaves is editor of Coenzyme Q10: From Fact to Fiction (2015), Mitochondrial Respiratory Chain Disorders: From Clinical Presentation to Diagnosis and Treatment (2019) and author of 160 peer-review research papers.   Guest websites and links:   https://www.researchgate.net/profile/Iain-Hargreaves   Selection of our guest's publications: Mantle D, Dewsbury M, Hargreaves IP. The Ubiquinone-Ubiquinol Redox Cycle and Its Clinical Consequences: An Overview. Int J Mol Sci. 2024 Jun 20;25(12):6765. Mantle D, Hargreaves IP, Domingo JC, Castro-Marrero J. Mitochondrial Dysfunction and Coenzyme Q10 Supplementation in Post-Viral Fatigue Syndrome: An Overview. Int J Mol Sci. 2024 Jan 1;25(1):574. Mantle D, Hargreaves I. Coenzyme Q10 and the Blood-Brain Barrier: An Overview. J Clin Med. 2025 Apr 16;14(8):2748. Staiano C, García-Corzo L, Mantle D, Turton N, Millichap LE, Brea-Calvo G, Hargreaves I. Biosynthesis, Deficiency, and Supplementation of Coenzyme Q. Antioxidants (Basel). 2023 Jul 21;12(7):1469. Mantle D, Heaton RA, Hargreaves IP. Coenzyme Q10, Ageing and the Nervous System: An Overview. Antioxidants (Basel). 2021 Dec 21;11(1):2.