Dr. Megan Kruse & Dr. Carol Tweed – ESR1 Mutation Monitoring & Oral SERDs in Metastatic Breast Cancer

Are we moving past the traditional "wait for progression" model in HR+ mBC? In this episode of CHM Conversations, Dr. Megan Kruse and Dr. Carol Tweed examine how molecular resistance monitoring is redefining the treatment timeline.The discussion highlights the shift toward a proactive approach, focusing on the clinical utility of serial ctDNA testing as seen in the SERENA-6 trial. Dr. Kruse and Dr. Tweed discuss how identifying ESR1 mutations early allows for a more precise transition to oral SERDs, helping to preserve endocrine sensitivity and delay the need for more aggressive ADC or chemotherapy regimens.The clinicians also dive into the nuances of sequencing endocrine therapies and other targeted therapies, and specifically how molecular data helps time the move to next-generation agents. They address the "real-world" side of precision medicine—from implementing liquid biopsy workflows and navigating insurance to managing patient anxiety and monitoring for treatment-related side effects.A valuable perspective for oncology clinicians looking to master the next generation of biomarker-driven care.🎧 Watch more expert-led oncology conversations from CHM Conversations.#BreastCancer #MetastaticBreastCancer #HRPositive #HER2Negative #ESR1 #OralSERD #Camizestrant #SERENA6 #ctDNA #LiquidBiopsy #PrecisionOncology #TargetedTherapy #EndocrineTherapy #CDK46 #ADC #MedicalOncology #BreastOncology #CommunityHealthMedia–Thanks for watching!Our podcasts are also available on: • Spotify - https://spotf.fi/chm-podcast • Amazon Music - https://amazn.so/chm-podcast • Apple Podcast - https://podcasts.apple.com/us/podcast/community-health-media/id1837428248 • Castbox - https://castbox.fm/vh/6735434 • Goodpods - https://goodpods.com/profile/chm-111066 • iHeartRadio - https://iheart.com/podcast/291542082 • Pocket Casts - https://pca.st/3ncdh11o–Community Health Media (CHM) is your full service healthcare communications partner, combining our production expertise with targeted multi-channel campaigns. We connect companies and healthcare brands with key opinion leaders, patients, and consumers through compelling content and live experiences.We’re an integrated marketing company that produces world-class content and curated peer to peer live experiences.We specialize in: • Peer to peer interviews, panels & round-tables • Curated live events & conferences • Professional in-depth content & research updates • Interactive learning modules & webinars • Live & on-demand webcasts & podcastsLearn more about us here - https://communityhealth.media