Dr. Michael Roizen:  Can 90 Feel Like 40?

Longer life is changing what people over 50 expect from medicine, themselves, and the decades ahead. In this encore episode, Dr. Michael Roizen argues that aging is increasingly shaped by informed choices, while the current culture surrounding longevity struggles to separate useful evidence from expensive fads.Roizen examines the science behind epigenetic switches, protein cycling, metformin, stem cells, cardiovascular risk, and balance. The conversation offers a practical framework for evaluating new claims, protecting physical and cognitive function, and asking better questions before adopting a new treatment or supplement.Join Us at the 2026 Super Age Games! Visit games.superage.com to learn more.Special Thanks to Our SponsorsTrue Nutrition: Stop settling for what’s on the shelf and build the protein blend that fits your lifestyle at truenutrition.com/AGEIST and use code AGEIST for 20% off your first custom blend.LMNT Electrolytes: Try the all-new Lemonade Iced Tea! Our #1 electrolytes for optimal hydration. Get a free 8-count Sample Pack of LMNT’s most popular drink mix flavors with any purchase by using our link here. Find your favorite LMNT flavor, or share with a friend.Timeline Nutrition: Our favorite supplement for cell support and mitochondrial function. Listeners can now get 20% off their first Timeline purchase by using the code “AGEIST” at checkout at TimelineNutrition.com/ageist.Key Moments“You’re a better genetic engineer for you than anyone else who went to Caltech or MIT.”"Stressing the muscle not only repairs the muscle, but it turns on a gene that produces a small protein, which gets to the brain and makes the brain bigger. That’s why physical activity, we think, is so good for memory.""Can we make a hundred year old person a 40 year old person? In other words, can we extend the period of life between when you’re most productive, your 40s to 60s, to being between 40 and 90? And that’s where a lot of the aging mechanism research is going."Connect With Dr. RoizenCleveland Clinic InstagramLinkedInXFacebookBook: The Great Age RebootConnect with AGEISTNewsletterInstagramWebsiteLinkedInClick Here for the full interview transcript.Say hi to the AGEIST team!