Dr. Paul Kolodzik: GLP-1s for Alcohol Abuse episode artwork

EPISODE · Sep 11, 2025 · 1H

Dr. Paul Kolodzik: GLP-1s for Alcohol Abuse

from AGEIST

How do you treat alcohol use disorder (formerly called alcoholism) without requiring total abstinence? This week, Dr. Paul Kolodzik returns to The AGEIST Podcast to discuss his pioneering work around GLP-1s: using these medications to help people reduce their alcohol intake. Drawing on his background in emergency and addiction medicine, Dr. Kolodzik outlines how these off-label uses can drastically reduce consumption, often by 60–70%, even in heavy drinkers. Learn why harm reduction, not abstinence, is a realistic and medically valid path for many and how medication paired with behavior change is reshaping addiction treatment today.How long will you live? Take our quiz today to find out at ageist.com/longevity-quiz!Special Thanks to Our SponsorsOur Place: The top cookware brand for non-toxic, PFA-free pots and pans. Use the code “AGEIST” for 10% off at fromourplace.com. fatty15: C15:0 is the first essential fatty acid to be discovered in over 90 years, and fatty15 is on a mission to optimize your C15:0 levels to help support your long-term health and wellness—especially as you age. You can get an additional 15% off their 90-day subscription Starter Kit by going to fatty15.com/AGEIST and using the code “AGEIST” at checkout.Maui Nui: The cleanest, most nutrient-dense red meat out there–high in protein, rich in antioxidants, and ethically harvested. Their new, subscription-only Ohana Reserve Aged Cuts are aged for 14 days to make for unforgettable flavor, plus their to-go venison sticks are perfect for healthy snacking. Right now, Maui Nui is offering a free 12-pack of their jerky sticks with your first order of $79 or more. Just go to mauinuivenison.com/ageist to grab yours.Key Moments“The better way to go for many people is to be completely abstinent. But I don’t think it’s the only way to go.”“Almost universally, people that are put on GLP-1s decrease their drinking.”“Alcohol withdrawal kills people... opiate withdrawal feels terrible, but it doesn’t kill people.”Connect with Dr. KolodzikWebsite (The Metabolic MD)North Dayton Addiction & Recovery ServicesConnect with AGEISTNewsletterInstagramWebsiteLinkedInClick Here for the full interview transcript.Say hi to the AGEIST team!

How do you treat alcohol use disorder (formerly called alcoholism) without requiring total abstinence? This week, Dr. Paul Kolodzik returns to The AGEIST Podcast to discuss his pioneering work around GLP-1s: using these medications to help people reduce their alcohol intake. Drawing on his background in emergency and addiction medicine, Dr. Kolodzik outlines how these off-label uses can drastically reduce consumption, often by 60–70%, even in heavy drinkers. Learn why harm reduction, not abst...

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Dr. Paul Kolodzik: GLP-1s for Alcohol Abuse

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How do you treat alcohol use disorder (formerly called alcoholism) without requiring total abstinence? This week, Dr. Paul Kolodzik returns to The AGEIST Podcast to discuss his pioneering work around GLP-1s: using these medications to help people...

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