Dr. Rao & Dr. Nasrazadani – The Second-Line Landscape for HR+/HER2- mBC: The Role of Capivasertib

The second-line landscape for HR+/HER2- metastatic breast cancer is shifting rapidly with the detection of truncal mutations. In this episode of CHM Conversations, Dr. Ruta Rao and Dr. Azadeh Nasrazadani discuss how the detection of PIK3CA, AKT, and PTEN mutations is redefining the role of capivasertib.The clinicians differentiate the clinical application of capivasertib from other targeted agents like alpelisib and inavolisib, exploring how mechanistic differences and biomarker profiles influence patient selection. A central focus is placed on mastering the safety profile of these agents, providing practical strategies for managing stomatitis, diarrhea, and hyperglycemia to ensure treatment continuity and optimize patient outcomes.An essential resource for oncology teams navigating the complexities of the PI3K/AKT/PTEN pathway and optimizing supportive care in the second-line metastatic breast cancer landscape.🎧 Watch more expert-led oncology conversations from CHM Conversations.#BreastCancer #HRPositive #MetastaticBreastCancer #PrecisionOncology #BiomarkerTesting #PIK3CA #ESR1 #Capivasertib #LiquidBiopsy #EndocrineTherapy #CommunityHealthMedia–Thanks for watching!Our podcasts are also available on: • Spotify - https://spotf.fi/chm-podcast • Amazon Music - https://amazn.so/chm-podcast • Apple Podcast - https://podcasts.apple.com/us/podcast/community-health-media/id1837428248 • Castbox - https://castbox.fm/vh/6735434 • Goodpods - https://goodpods.com/profile/chm-111066 • iHeartRadio - https://iheart.com/podcast/291542082 • Pocket Casts - https://pca.st/3ncdh11o–Community Health Media (CHM) is your full service healthcare communications partner, combining our production expertise with targeted multi-channel campaigns. We connect companies and healthcare brands with key opinion leaders, patients, and consumers through compelling content and live experiences.We’re an integrated marketing company that produces world-class content and curated peer to peer live experiences.We specialize in: • Peer to peer interviews, panels & round-tables • Curated live events & conferences • Professional in-depth content & research updates • Interactive learning modules & webinars • Live & on-demand webcasts & podcastsLearn more about us here - https://communityhealth.media