Dr. Raquel Fleskes – Using Ancient DNA to interpret historical sites

Dr. Raquel Fleskes of Dartmouth joins the show to talk about her work using ancient DNA to uncover the past in the Tidewater and South Carolina. Most people think about ancient DNA being used for, well, ancient skeletons, but ancient DNA can also be used in more recent contexts to illuminate the near past. We also chatted about ways to make ancient DNA work more accessible to descendent communities. Recommendations Dr. Fleske's lab page Dr. Fleske's staff profile at Dartmouth Dr. Fleske's Google Scholar page Jamestown Rediscovery website Fleskes, R. E., H. M. Palacios, H. Budner, et al. (2025). "Archaeogenomic Analysis of Nineteenth-Century Burials at Saint Mary's Basilica: An Intersectional Analysis of Religion, Race, and Migration." Am J Biol Anthropol, 187, no. 4: e70110. https://doi.org/10.1002/ajpa.70110. Masur, L., Fleskes, R., Schurr, T., Brown, D., Harpole, T., Pollard, P., Alukonis, L., Horsley, T., et al. (2025). "Let Perpetual Light Shine upon Them": Forgetting and Remembering Segregated Catholic Cemeteries." American Antiquity. 91. 1-24. 10.1017/aaq.2025.10103. Fleskes, R.E., Gilmore, J.K., Oubré, L.S., Ofunniyin, A.A., Cabana, G.S. and Schurr, T.G. (2025). "Immersive Videography of Ancient DNA Extraction for Community Engagement and Educational Initiatives by the Anson Street African Burial Ground Project." Am J Biol Anthropol, 186: e25055. https://doi.org/10.1002/ajpa.25055 Fleskes, R.E., Johnson, S.J., Honap, T.P. et al. (2024). "Oral microbial diversity in 18th century African individuals from South Carolina." Commun Biol 7, 1213. https://doi.org/10.1038/s42003-024-06893-0 R.E. Fleskes, G.S. Cabana, J.K. Gilmore, C. Juarez, E. Karcher, L. Oubré, G. Mishoe, A.A. Ofunniyin, & T.G. Schurr. (2023). "Community-engaged ancient DNA project reveals diverse origins of 18th-century African descendants in Charleston, South Carolina." Proc. Natl. Acad. Sci. U.S.A. 120 (3) e2201620120, https://doi.org/10.1073/pnas.2201620120. Fleskes, R.E., Johnson, S.J., Honap, T.P. et al. (2024). "Oral microbial diversity in 18th century African individuals from South Carolina." Commun Biol 7, 1213. https://doi.org/10.1038/s42003-024-06893-0. Raquel E. Fleskes, Alyssa C. Bader, Krystal S. Tsosie, Jennifer K. Wagner, Katrina G. Claw, Nanibaa' A. Garrison. (2022). "Ethical Guidance in Human Paleogenomics: New and Ongoing Perspectives." Annual Review Genomics and Human Genetics. 23:627-652. https://doi.org/10.1146/annurev-genom-120621-090239 Fleskes RE, Ofunniyin AA, Gilmore JK, et al. (2021). "Ancestry, health, and lived experiences of enslaved Africans in 18th century Charleston: An osteobiographical analysis." Am J Phys Anthropol.175:3–24. https://doi.org/10.1002/ajpa.24149 Källén, A. (2025). The Trouble with Ancient DNA: Telling Stories of the Past with Genomic Science. University of Chicago Press. The X-Files Scooby-Doo