Dr. Rebecca Shatsky & Dr. Reva Basho - Sequencing PI3K/AKT Therapies in Metastatic Breast Cancer

How are clinicians navigating the growing number of targeted therapy options in HR-positive, HER2-negative metastatic breast cancer?In this CHM Conversations episode, Drs. Rebecca Shatsky and Reva Basho discuss the critical role of genomic profiling—specifically PIK3CA, AKT, PTEN, and ESR1—in guiding second-line treatment for HR+/HER2- metastatic breast cancer.The panel compares the clinical use of alpelisib, capivasertib, and inavolisib, focusing on how to sequence these agents after progression on CDK4/6 inhibitors. The experts share practical strategies for managing class-specific toxicities and discuss the future of oral SERDs and combination therapies in personalizing patient care.A valuable discussion for oncologists and healthcare professionals navigating precision medicine and targeted sequencing strategies in breast oncology.🎧 Watch more expert-led oncology conversations from CHM Conversations.#BreastCancer #MetastaticBreastCancer #HRPositive #HER2Negative #Oncology #PIK3CA #AKT #PTEN #Capivasertib #Alpelisib #Inavolisib #ctDNA #PrecisionOncology #TargetedTherapy #MedicalOncology #BreastOncology #CommunityHealthMedia–Thanks for watching!Our podcasts are also available on: • Spotify - https://spotf.fi/chm-podcast • Amazon Music - https://amazn.so/chm-podcast • Apple Podcast - https://podcasts.apple.com/us/podcast/community-health-media/id1837428248 • Castbox - https://castbox.fm/vh/6735434 • Goodpods - https://goodpods.com/profile/chm-111066 • iHeartRadio - https://iheart.com/podcast/291542082 • Pocket Casts - https://pca.st/3ncdh11o–Community Health Media (CHM) is your full service healthcare communications partner, combining our production expertise with targeted multi-channel campaigns. We connect companies and healthcare brands with key opinion leaders, patients, and consumers through compelling content and live experiences.We’re an integrated marketing company that produces world-class content and curated peer to peer live experiences.We specialize in: • Peer to peer interviews, panels & round-tables • Curated live events & conferences • Professional in-depth content & research updates • Interactive learning modules & webinars • Live & on-demand webcasts & podcastsLearn more about us here - https://communityhealth.media