Dr. Ryan Vandrey on Cannabis

In this episode, Brent speaks with Dr. Ryan Vandrey of Johns Hopkins to take a closer look at cannabis. With more than two decades of research in behavioral pharmacology, Dr. Vandrey walks through how THC and CBD actually interact with the brain and body, why addiction is often misunderstood, and how factors like dose, delivery method, and individual biology can completely change the experience. The conversation examines where cannabis has proven medical value, where the data is still thin, and how legalization has outpaced the kind of rigorous science typically required for new therapies. They also explore the realities of withdrawal, the overlap with mental health and sleep, and what emerging research could reveal about more targeted, effective uses in the future. It's a nuanced, data-driven look at a topic that's often oversimplified, hope you enjoy.