DrBeen#84: Researchers Find Flaws with mRNA Therapeutics

An article from the University of Cambridge contains this statement, "Researchers have discovered that misreading of therapeutic mRNAs by the cell’s decoding machinery can cause an unintended immune response in the body. They have identified the sequence within the mRNA that causes this to occur and found a way to prevent ‘off-target’ immune responses to enable the safer design of future mRNA therapeutics." Let’s review. DrBeen: Medical Education Onlinehttps://www.drbeen.com/ FLCCC | Front Line COVID-19 Critical Care Alliancehttps://covid19criticalcare.com/ Reference list from Dec. 8, 2023Researchers redesign future mRNA therapeutics to prevent potentially harmful immune responses | University of Cambridgehttps://www.cam.ac.uk/research/news/researchers-redesign-future-mrna-therapeutics-to-prevent-potentially-harmful-immune-responses N1-methylpseudouridylation of mRNA causes +1 ribosomal frameshifting | Naturehttps://www.nature.com/articles/s41586-023-06800-3 The Shape and Structure of Proteins - Molecular Biology of the Cell - NCBI Bookshelfhttps://www.ncbi.nlm.nih.gov/books/NBK26830/#:~:text=A%20protein%20molecule%20is%20made,one%20molecule%20to%20the%20next Ribosomes, Transcription, Translation | Learn Science at Scitablehttps://www.nature.com/scitable/topicpage/ribosomes-transcription-and-translation-14120660/#:~:text=Recall%20that%20mRNA%20molecules%20are,protein%20as%20it%20is%20synthesized Genetic code - Wikipediahttps://en.wikipedia.org/wiki/Genetic_code DNA and RNA codon tables - Wikipediahttps://en.wikipedia.org/wiki/DNA_and_RNA_codon_tables Pseudouridine - Wikipediahttps://en.wikipedia.org/wiki/Pseudouridine Modifications in an Emergency: The Role of N1-Methylpseudouridine in COVID-19 Vaccines | ACS Central Sciencehttps://pubs.acs.org/doi/10.1021/acscentsci.1c00197 Ribonucleotide - Wikipediahttps://en.wikipedia.org/wiki/Ribonucleotide#:~:text=In%20biochemistry%2C%20a%20ribonucleotide%20is,monomeric%20building%20blocks%20for%20RNA Translation: DNA to mRNA to Protein | Learn Science at Scitablehttps://www.nature.com/scitable/topicpage/translation-dna-to-mrna-to-protein-393/#:~:text=The%20process%20of%20translation%20can,transcription%20as%20well%20as%20tRNA.&text=The%20genes%20in%20DNA%20encode,the%20functions%20necessary%20for%20life Frontiers | On programmed ribosomal frameshifting: the alternative proteomeshttps://www.frontiersin.org/articles/10.3389/fgene.2012.00242/full#:~:text=Frameshifting%20is%20a%20process%20whereby,downstream%20(%E2%88%921%20frameshift) Disclaimer:
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