DrBeen#85: mRNA Vaccines Produce Off-Target Proteins

What are the off-target proteins produced by mRNA vaccines? Can these proteins cause harm? What is the mechanism of their production? Let's review. An article on University of Cambridge contains this statement, "Researchers have discovered that misreading of therapeutic mRNAs by the cell’s decoding machinery can cause an unintended immune response in the body. They have identified the sequence within the mRNA that causes this to occur and found a way to prevent ‘off-target’ immune responses to enable the safer design of future mRNA therapeutics." DrBeen: Medical Education Online https://www.drbeen.com/ FLCCC | Front Line COVID-19 Critical Care Alliance https://covid19criticalcare.com/ URL list from Friday, Dec. 15, 2023 Long Story Short With Dr. Been - FLCCC | Front Line COVID-19 Critical Care Alliance https://covid19criticalcare.com/courses/long-story-short-with-dr-been/ Researchers redesign future mRNA therapeutics to prevent potentially harmful immune responses | University of Cambridge https://www.cam.ac.uk/research/news/researchers-redesign-future-mrna-therapeutics-to-prevent-potentially-harmful-immune-responses N1-methylpseudouridylation of mRNA causes +1 ribosomal frameshifting | Nature https://www.nature.com/articles/s41586-023-06800-3 Interferon gamma - Wikipedia https://en.wikipedia.org/wiki/Interferon_gamma The Shape and Structure of Proteins - Molecular Biology of the Cell - NCBI Bookshelf https://www.ncbi.nlm.nih.gov/books/NBK26830/#:~:text=A%20protein%20molecule%20is%20made,one%20molecule%20to%20the%20next . Ribosomes, Transcription, Translation | Learn Science at Scitable https://www.nature.com/scitable/topicpage/ribosomes-transcription-and-translation-14120660/#:~:text=Recall%20that%20mRNA%20molecules%20are,protein%20as%20it%20is%20synthesized . Genetic code - Wikipedia https://en.wikipedia.org/wiki/Genetic_code DNA and RNA codon tables - Wikipedia https://en.wikipedia.org/wiki/DNA_and_RNA_codon_tables Pseudouridine - Wikipedia https://en.wikipedia.org/wiki/Pseudouridine Modifications in an Emergency: The Role of N1-Methylpseudouridine in COVID-19 Vaccines | ACS Central Science https://pubs.acs.org/doi/10.1021/acscentsci.1c00197 Ribonucleotide - Wikipedia https://en.wikipedia.org/wiki/Ribonucleotide#:~:text=In%20biochemistry%2C%20a%20ribonucleotide%20is,monomeric%20building%20blocks%20for%20RNA . Translation: DNA to mRNA to Protein | Learn Science at Scitable https://www.nature.com/scitable/topicpage/translation-dna-to-mrna-to-protein-393/#:~:text=The%20process%20of%20translation%20can,transcription%20as%20well%20as%20tRNA.&text=The%20genes%20in%20DNA%20encode,the%20functions%20necessary%20for%20life . Frontiers | On programmed ribosomal frameshifting: the alternative proteomes https://www.frontiersin.org/articles/10.3389/fgene.2012.00242/full#:~:text=Frameshifting%20is%20a%20process%20whereby,downstream%20(%E2%88%921%20frameshift) . Disclaimer: This video is not intended to provide assessment, diagnosis, treatment, or medical advice; it also does not constitute provision of healthcare services. The content provided in this video is for informational and educational purposes only. Please consult with a physician or healthcare professional regarding any medical or mental health related diagnosis or treatment. No information in this video should ever be considered as a substitute for advice from a healthcare professional.