Drug-Drug Interactions

A strong focus on cytochrome P450 (CYP) enzymes and drug transporters as primary determinants of pharmacokinetics and drug-drug interactions. The text explores the role of specific CYP isoforms (like CYP3A4, CYP2D6, and CYP2C9) in drug clearance, detailing their substrates, inhibitors, and inducers, and discussing the prevalence and clinical significance of their inhibition. Furthermore, it examines in vitro and in vivo methodologies used to study drug metabolism and transport, including the use of probe drugs and membrane vesicles, and addresses the complex role of both hepatic and intestinal components in first-pass metabolism. The source also touches upon the regulatory and toxicological perspectives of predicting and managing adverse metabolic drug interactions in clinical settings and drug development.You can listen and download our episodes for free on more than 10 different platforms:https://linktr.ee/pharmacy_simpleProduced by:https://www.podcaistudio.com/