E185: What makes some medicines too thick? [SJK Audio Edition]

Read this article at: https://www.sciencejournalforkids.org/articles/what-makes-some-medicines-too-thick/ or watch at: https://youtu.be/zcofWUPH4nwSummary: Researchers used computer simulation models to investigate why medicines become viscous at high concentrations.Abstract: A lot of thought goes into the creation of a medicine. One important consideration is how the medicine is given. Some medicines can be given in pills or sprays. Others need to be injected using a syringe. Some even require procedures in a medical center. The physical properties of the medicine will determine how it can be given. So, what if we could change those physical properties on demand? We wanted to investigate the physical properties of medicines containing monoclonal antibodies. They are used to treat cancer and autoimmune diseases. They often have to be given intravenously at a medical center because these medicines can get very viscous (thick). We wanted to know why. So we developed several models and ran computer simulations to see what was happening. We found that interactions between the antibodies and charged particles in the solution created temporary clusters. We can use this information to modify medicines and make them more accessible.You are one of half a million educators in the U.S. who use our articles and videos in class. All our content is FREE, no paywalls, no need to subscribe. But recent federal cuts have made it hard for us to win grants to fund our mission. We are a small non-profit, and without support, we may not make it.If you enjoy our content, please consider donating - https://www.sciencejournalforkids.org/support-us.html This is a public episode. If you would like to discuss this with other subscribers or get access to bonus episodes, visit sciencejournalforkids.substack.com