E195 - Dr. Mei Rui: The Science of Sound & Music as Medicine

Dr. Mei Rui is a Yale-trained molecular biophysicist, concert pianist, and clinical researcher at MD Anderson Cancer Center, where she runs trials on the measurable effects of music on the human body. In this conversation, we explore what actually happens in the brain the moment music enters it, why the auditory system is the first sense to develop in the womb and the last to go when we die, and how something as accessible as a curated playlist can outperform FDA-approved pharmaceuticals in reducing cortisol.What We Dive Into:1. Music is not a supplement to healing. In the right context, it is the intervention.2. The brain responds differently when you actually show up for the music.3. A longitudinal study in twins showed that three to four years of musical training reduced the risk of Alzheimer's and cognitive decline by 64%, an effect size found in no other single activity.THANK YOU TO OUR SPONSORS:Oneskin — Code KNOWTHYSELF for 15% off - Limited time only!https://oneskin.co/KNOWTHYSELFBASED Body Works — Code KNOWTHYSELF for 20% and a free toiletry bag!https://www.basedbodyworks.com___________00:00 Introduction: Dr. Mei Rui01:44 A Life Between Music and Science05:26 What Happens When Music Enters the Brain07:26 How the Brain Processes Sound and Music11:32 Why Minor Keys Feel Sad: The Science of Tonality14:37 Live Piano Demo: Matching Music to Mood19:06 Music in the Operating Room27:41 Music as Medicine: Clinical Applications29:10 The 32% Cortisol Study31:19 The 16 Compositional Elements of Healing Music35:11 Oxytocin, Familiarity, and the Parasympathetic Response36:18 Timbre and the Cello's Resemblance to a Mother's Voice42:31 Cymatics: Sound Made Visible45:16 The Ancient Roots of Music as Healing47:09 Listening vs. Playing an Instrument55:33 The Musician's Brain: Structural Differences57:46 Music Training and Protection Against Alzheimer's59:44 Music, Empathy, and Neural Synchrony1:01:36 The EEG Experiment: Reading André's Brain Live1:18:21 What the EEG Data Revealed1:22:26 Music, Flow State, and the Disappearance of Self1:26:55 Music as Spiritual Medicine1:30:23 How to Listen More Intentionally___________MORE FROM MEI✨Instagram: https://www.instagram.com/@meiruipianoMORE FROM KNOW THYSELF🎙️Spotify: https://spoti.fi/4bZMq9l🎧Apple: https://apple.co/4iATICX✨Instagram: https://www.instagram.com/knowthyself/🎬TikTok: https://www.tiktok.com/@andreduqum👥Facebook: https://www.facebook.com/knowthyselfbyandreduqum/🌐https://knowthyselfpodcast.com/MORE FROM ANDRÉ✨Instagram: https://www.instagram.com/@andreduqum💼Linkedin: https://www.linkedin.com/company/know-thyself-podcast📚Book recs: https://www.knowthyselfpodcast.com/book-list