E477 | Jeremy Uzan, Singular: Chasing Pure Performance, Generalist VCs & Why Europe is Ready for Science-Driven Founders

In this episode, is joined by , co-founder and GP at , for a look at how a “plain vanilla” approach to venture—driven by deep founder focus and relentless performance orientation — can be a powerful advantage. Together, they unpack the mechanics behind Singular’s model, how the team stays agile without a rigid thesis, and what it means to create an empowering internal culture. Singular is an early-stage venture capital firm born in Europe, committed to empowering European founders with global ambitions across all sectors, from Seed to Series B, with a strong focus on Series A companies.Jeremy also shares his evolving views on European talent, the rise of Paris as a startup epicenter, and why he believes we’re only just beginning to unlock the entrepreneurial potential of Europe’s scientific minds.Here’s what’s covered:02:00 – Should Generalist VCs Still Exist in Europe07:10 – Fundraising Like a Founder: How LPs Backed Fund I and II14:00 – Why Generalist Isn’t a Weakness—It’s Strategic16:25 – Diversification vs. Focus: Squaring LP Needs with Performance21:15 – Temporary Specialists: Sprinting Deep Into Sectors24:20 – From Zero to One on Markets: Learning via Founders27:15 – European Talent Post-COVID: What’s Changed30:00 – Paris Joins the Core of the European Ecosystem35:15 – The Rise of Science Entrepreneurs in Europe39:00 – Why Bio is the Next Big Tech Frontier